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Wound Contraction in Relation to Collagen Formation in Scorbutic Guinea-pigs

Department of Anatomy and Embryology, University College London

¹ Authors' address: Department of Anatomy & Embryology, University College London, Gower Street, W.C.1, U.K.

Received for publication 2 September 1955.

SUMMARY

A Wound in any mobile part of the skin of a mammal diminishes in area as it heals by a centripetal movement of the undamaged skin surrounding it. This movement, usually called wound contraction, depends on a pull exerted by the material within the wound (Lindquist, 1946; Abercrombie, Flint, & James, 1954; Billingham & Medawar, 1955). It is commonly believed that the effective force is developed by the newly formed collagen fibres. In a previous paper, however (Abercrombie, Flint, & James, 1954), we found that the course of the contraction of skin wounds in rats did not parallel the deposition of new collagen, chemically measured. This result, while certainly in no way conclusive by itself, suggested that the supposed role of collagen in contraction ought to be tested more stringently. This we have now done by measuring wounds made on guinea-pigs receiving a diet devoid of ascorbic acid.

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