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Studies on Embryonic Induction using Radioactive Tracers

Institute of Animal Genetics, Edinburgh

¹ Authors' address: Institute of Animal Genetics, West Mains Road, Edinburgh 9, U.K.

Received for publication 8 November 1955.

SUMMARY

The nature of the agent which brings about induction during the early development of vertebrates has been extraordinarily difficult to determine. As yet we are not even certain whether there is a passage of a comparatively massive quantity of material from the organizer into the reacting competent tissue, as is probably most usually assumed, or whether the action is primarily located at the surface of intercellular contact, as suggested by Weiss (cf.1947, 1950). Waddington & Goodhart (1949) showed that certain unnatural evocators (steroids) certainly penetrate the competent tissues, and can be recognized inside the reacting cells by their ultraviolet fluorescence. This rinding does not by any means solve theproblem as far as concerns the substances involved in natural induction. A possible method of attack here would seem to be the use of radioactive tracers.

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