QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lucas, D. R. Search for Related Content PubMed Articles by Lucas, D. R. Social Bookmarking                         What's this?

Inherited Retinal Dystrophy in the Mouse: its Appearance in Eyes and Retinae Cultured in vitro

Wernher Group for Research in Ophthalmological Genetics (Medical Research Council), Royal College of Surgeons

¹ Author's address: M.R.C. Radiobiological Unit, Atomic Energy Research Establishment, Harwell, Didcot, Berks., U.K.

Received for publication 1 April 1958.

SUMMARY

Certain strains of mice, such as C3H, exhibit a recessively inherited retinal dystrophy. This takes the form of a degeneration and complete disappearance of the visual cell layer; it begins on or about the 1 lth day of life and is nearly complete by the 19th day (Sorsby, Roller, Attfield, Davey, & Lucas, 1954). The process is remarkably uniform from litter to litter (Lucas & Newhouse, 1957).

In a previous paper (Lucas & Trowell, 1958) it was shown that eyes and retinae taken from 10-day-old normal (CBA) mice could be maintained in vitro for 8 days, during which time their structure was fairly well preserved and differentiation proceeded.

In the present work, eyes and retinae from dystrophic strains of mice have been cultured over a similar period to see if the dystrophy developed in vitro.

The eyes or retinae of 25 animals from 3 litters of the C3H strain, maintained at the M.R.C.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?