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Congenital Malformations in Mouse Embryos Induced by 8-Azaguanine

Department of Anatomy, Kyoto University

¹ Authors' address: Department of Anatomy, Faculty of Medicine, Kyoto University, Sakyoku, Kyoto. Japan.

Received for publication 8 April 1958.

SUMMARY

In recent years congenital malformations have been induced in higher mammals by such exogenous factors as nutritional deficiencies, anoxia, certain hormones, and chemicals (Fraser & Fainstat, 1951; Hickey, 1952; Wilson, 1954; Nishimura, 1956). This study was undertaken to ascertain whether 8-azaguanine, an antagonist to guanine, has a teratogenic effect on mouse embryos.

Female mice of the Japanese dd strain were mated at 3 to 5 months of age. On days 7 to 15 of pregnancy they were given a single intraperitoneal injection of 8-azaguanine solution (16 mg./c.c.) and then were sacrificed shortly before term to determine state of pregnancy and condition of the foetuses. Routine histological examinations were made of malformed organs and also of the placentae of affected embryos. As controls foetuses from 30 untreated mothers from the same colony were examined.

Table 1 shows the results of injection with 8-azaguanine at various times in gestation.

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