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The Dependence of the Embryonic Inductive Action of HeLa Cells on Their Growth Media

Zoological Laboratory and Department of Pathology, Section II, University of Helsinki

¹ Authors' address: Zoological Laboratory, University of Helsinki, Finland.

Received for publication 16 May 1958.

SUMMARY

Although the ability of adult tissues to regulate the differentiation of a competent ectoderm is tissue-specific within certain limits, this inductive capacity appears to be influenced by external factors (see Discussion). In the investigations to be presented here, the effect of various growth media on induction by cells grown in vitro was studied, the main purpose being to elucidate the relations between the inductive capacity of the tissues and the external factors. At the same time, it was our intention—by changing the growth medium—to ‘fractionate’ the inductive capacity of the tissues under known conditions in order to gain further insight into the question of the amount and quality of the inductive agents. Being concerned with malignant cells, this investigation was, in addition, intended as a further link in the chain of experiments by which we have studied the differences between normal and malignant tissues with regard to inductive capacity.

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