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Size regulation in the mouse embryo

II. The development of half embryos

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK

Accepted 14 July 1986

SUMMARY

The study describes an analysis of the development of mouse embryos halved at the 2-cell stage by the destruction of one blastomere, in comparison with control embryos of parallel derivation, at 2·5–13·5 days post coitum. The results showed that: (1) half embryos achieve size regulation some time between 7·5 and 10·5 days; (2) there is an indication that by 13·5 days half embryos may have again dropped back significantly in size relative to controls; (3) preregulation half embryos are slightly retarded developmental, but this does not wholly account for their smaller size: morphogenesis is not size-dependent; (4) early postimplantation half embryos contain a significantly decreased proportion of inner cell mass derivatives and increased proportion of trophectoderm derivatives when compared with controls.

A comparison is also made between the up-regulation of half embryos and the down-regulation of aggregate embryos, and it is suggested that size regulation may occur by delaying a change in the normal growth rate.

Key words: size regulation, mouse, half embryo, morphogenesis, growth