spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 7 Mar 2007
doi: 10.1242/dev.001255

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.001255v1
134/8/1617    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sugimori, M.
Right arrow Articles by Nakafuku, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sugimori, M.
Right arrow Articles by Nakafuku, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article: Development and Disease

Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord


Michiya Sugimori, Motoshi Nagao, Nicolas Bertrand, Carlos M. Parras, François Guillemot, and Masato Nakafuku*
* Author for correspondence (e-mail: masato.nakafuku{at}cchmc.org)

During development, the three major neural cell lineages, neurons, oligodendrocytes and astrocytes, differentiate in specific temporal orders at topologically defined positions. How the timing and position of their generation are coordinately regulated remains poorly understood. Here, we provide evidence that the transcription factors Pax6, Olig2 and Nkx2.2 (Nkx2-2), which define the positional identity of multipotent progenitors early in development, also play crucial roles in controlling the timing of neurogenesis and gliogenesis in the developing ventral spinal cord. We show that each of these factors has a unique ability to either enhance or inhibit the activities of the proneural helix-loop-helix (HLH) factors Ngn1 (Neurog1), Ngn2 (Neurog2), Ngn3 (Neurog3) and Mash1 (Ascl1), and the inhibitory HLH factors Id1 and Hes1, thereby regulating both the timing of differentiation of multipotent progenitors and their fate. Consistent with this, dynamic changes in their co-expression pattern in vivo are closely correlated to stage- and domain-specific generation of three neural cell lineages. We also show that genetic manipulations of their temporal expression patterns in mice alter the timing of differentiation of neurons and glia. We propose a molecular code model whereby the combinatorial actions of two classes of transcription factors coordinately regulate the domain-specific temporal sequence of neurogenesis and gliogenesis in the developing spinal cord.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
A. Garcia-Bellido and J. F. de Celis
The Complex Tale of the achaete-scute Complex: A Paradigmatic Case in the Analysis of Gene Organization and Function During Development
Genetics, July 1, 2009; 182(3): 631 - 639.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B.-Y. Hu, Z.-W. Du, X.-J. Li, M. Ayala, and S.-C. Zhang
Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects
Development, May 1, 2009; 136(9): 1443 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Nagao, K. Campbell, K. Burns, C.-Y. Kuan, A. Trumpp, and M. Nakafuku
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway
J. Cell Biol., December 29, 2008; 183(7): 1243 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Galichet, F. Guillemot, and C. M. Parras
Neurogenin 2 has an essential role in development of the dentate gyrus
Development, June 1, 2008; 135(11): 2031 - 2041.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Sugimori, M. Nagao, C. M. Parras, H. Nakatani, M. Lebel, F. Guillemot, and M. Nakafuku
Ascl1 is required for oligodendrocyte development in the spinal cord
Development, April 1, 2008; 135(7): 1271 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. White, C. Lee May, R. N. Lamounier, J. E. Brestelli, and K. H. Kaestner
Defining Pancreatic Endocrine Precursors and Their Descendants
Diabetes, March 1, 2008; 57(3): 654 - 668.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. J. Kim, C. T. Leung, R. R. Reed, and J. E. Johnson
In Vivo Analysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis
J. Neurosci., November 21, 2007; 27(47): 12764 - 12774.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Guillemot
Spatial and temporal specification of neural fates by transcription factor codes
Development, November 1, 2007; 134(21): 3771 - 3780.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007