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Development ePress online publication date 17 Oct 2007
doi: 10.1242/dev.002741

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Research article

Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development


Kavita S. Oommen and Anna P. Newman*
* Author for correspondence (e-mail: apnewman{at}uh.edu)

The Notch pathway is the key signal for many cell fate decisions in the nematode Caenorhabditis elegans including the uterine {pi} cell fate, crucial for a proper uterine-vulval connection and egg laying. Expression of the egl-13 SOX domain transcription factor is specifically upregulated upon induction of the {pi} lineage and not in response to other LIN-12/Notch-mediated decisions. We determined that dual regulation by LIN-12 and FOS-1 is required for egl-13 expression at specification and for complete rescue of egl-13 mutants. We found that fos-1 mutants exhibit uterine defects and fail to express {pi} markers. We show that FOS-1 is expressed at {pi} cell specification and can bind in vitro to egl-13 upstream regulatory sequence (URS) as a heterodimer with C. elegans Jun.


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© The Company of Biologists Ltd 2007