spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 16 May 2007
doi: 10.1242/dev.003814

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.003814v1
134/12/2237    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by D'Autréaux, F.
Right arrow Articles by Gershon, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by D'Autréaux, F.
Right arrow Articles by Gershon, M. D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia


Fabien D'Autréaux, Yuka Morikawa, Peter Cserjesi, and Michael D. Gershon*
* Author for correspondence (e-mail: mdg4{at}columbia.edu)

Hand genes encode basic helix-loop-helix transcription factors that are expressed in the developing gut, where their function is unknown. We now report that enteric Hand2 expression is limited to crest-derived cells, whereas Hand1 expression is restricted to muscle and interstitial cells of Cajal. Hand2 is developmentally regulated and is intranuclear in precursors but cytoplasmic in neurons. Neurons develop in explants from wild-type but not Hand2-/- bowel, although, in both, crest-derived cells are present and glia arise. Similarly, small interfering RNA (siRNA) silencing of Hand2 in enteric crest-derived cells prevents neuronal development. Terminally differentiated enteric neurons do not develop after conditional inactivation of Hand2 in migrating crest-derived cells; nevertheless, conditional Hand2 inactivation does not prevent precursors from expressing early neural markers. We suggest that enteric neuronal development occurs in stages and that Hand2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
Y. Morikawa, A. Zehir, E. Maska, C. Deng, M. D. Schneider, Y. Mishina, and P. Cserjesi
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways
Development, November 1, 2009; 136(21): 3575 - 3584.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M.-T. Liu, Y.-H. Kuan, J. Wang, R. Hen, and M. D. Gershon
5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice
J. Neurosci., August 5, 2009; 29(31): 9683 - 9699.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Funato, S. L. Chapman, M. D. McKee, H. Funato, J. A. Morris, J. M. Shelton, J. A. Richardson, and H. Yanagisawa
Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2
Development, February 15, 2009; 136(4): 615 - 625.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. Morikawa and P. Cserjesi
Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field Development
Circ. Res., December 5, 2008; 103(12): 1422 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Nekrep, J. Wang, T. Miyatsuka, and M. S. German
Signals from the neural crest regulate beta-cell mass in the pancreas
Development, June 15, 2008; 135(12): 2151 - 2160.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007