spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 15 Aug 2007
doi: 10.1242/dev.005132

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.005132v1
134/18/3283    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brugmann, S. A.
Right arrow Articles by Helms, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brugmann, S. A.
Right arrow Articles by Helms, J. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Wnt signaling mediates regional specification in the vertebrate face


Samantha A. Brugmann, L. Henry Goodnough, Alex Gregorieff, Philipp Leucht, Derk ten Berge, Christophe Fuerer, Hans Clevers, Roel Nusse, and Jill A. Helms*
* Author for correspondence (e-mail: jhelms{at}stanford.edu)

At early stages of development, the faces of vertebrate embryos look remarkably similar, yet within a very short timeframe they adopt species-specific facial characteristics. What are the mechanisms underlying this regional specification of the vertebrate face? Using transgenic Wnt reporter embryos we found a highly conserved pattern of Wnt responsiveness in the developing mouse face that later corresponded to derivatives of the frontonasal and maxillary prominences. We explored the consequences of disrupting Wnt signaling, first using a genetic approach. Mice carrying compound null mutations in the nuclear mediators Lef1 and Tcf4 exhibited radically altered facial features that culminated in a hyperteloric appearance and a foreshortened midface. We also used a biochemical approach to perturb Wnt signaling and found that in utero delivery of a Wnt antagonist, Dkk1, produced similar midfacial malformations. We tested the hypothesis that Wnt signaling is an evolutionarily conserved mechanism controlling facial morphogenesis by determining the pattern of Wnt responsiveness in avian faces, and then by evaluating the consequences of Wnt inhibition in the chick face. Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
L. Song, Y. Li, K. Wang, Y.-Z. Wang, A. Molotkov, L. Gao, T. Zhao, T. Yamagami, Y. Wang, Q. Gan, et al.
Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
Development, September 15, 2009; 136(18): 3161 - 3171.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Hu and R. S. Marcucio
A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm
Development, January 1, 2009; 136(1): 107 - 116.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. He, W. Xiong, X. Yu, R. Espinoza-Lewis, C. Liu, S. Gu, M. Nishita, K. Suzuki, G. Yamada, Y. Minami, et al.
Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development
Development, December 1, 2008; 135(23): 3871 - 3879.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. T. Chiquet, S. H. Blanton, A. Burt, D. Ma, S. Stal, J. B. Mulliken, and J. T. Hecht
Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate
Hum. Mol. Genet., July 15, 2008; 17(14): 2212 - 2218.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. Pantalacci, A. Chaumot, G. Benoit, A. Sadier, F. Delsuc, E. J. P. Douzery, and V. Laudet
Conserved Features and Evolutionary Shifts of the EDA Signaling Pathway Involved in Vertebrate Skin Appendage Development
Mol. Biol. Evol., May 1, 2008; 25(5): 912 - 928.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007