|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search | ||||
The fully linked HTML version of this article has now been published.
The Drosophila wing primordium is defined by expression of the selector gene vestigial (vg) in a discrete subpopulation of cells within the wing imaginal disc. Following the early segregation of the disc into dorsal (D) and ventral (V) compartments, vg expression is governed by signals generated along the boundary between the two compartments. Short-range DSL (Delta/Serrate/LAG-2)-Notch signaling between D and V cells drives vg expression in 'border' cells that flank the boundary. It also induces these same cells to secrete the long-range morphogen Wingless (Wg), which drives vg expression in surrounding cells up to 25-30 cell diameters away. Here, we show that Wg signaling is not sufficient to activate vg expression away from the D-V boundary. Instead, Wg must act in combination with a short-range signal produced by cells that already express vg. We present evidence that this vg-dependent, vg-inducing signal feeds forward from one cell to the next to entrain surrounding cells to join the growing wing primordium in response to Wg. We propose that Wg promotes the expansion of the wing primordium following the D-V segregation by fueling this non-autonomous autoregulatory mechanism.
This article has been cited by other articles:
Development ePress online publication date 18 Jul 2007
doi: 10.1242/dev.006411
This Article 
Full Text (PDF)
All Versions of this Article:
dev.006411v1
134/16/3001
most recent
Alert me when this article is cited
Alert me if a correction is posted
Services
Email this article to a friend
Similar articles in this journal
Similar articles in PubMed
Alert me to new issues of the journal
Download to citation manager
Citing Articles
Citing Articles via HighWire
Citing Articles via Google Scholar
Google Scholar
Articles by Zecca, M.
Articles by Struhl, G.
Search for Related Content
PubMed
PubMed Citation
Articles by Zecca, M.
Articles by Struhl, G.
Social Bookmarking
What's this?
Research article
Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation
* Author for correspondence (e-mail: gs20{at}columbia.edu)
CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
F. Hamaratoglu, K. Basler, and M. Affolter
Confronting Morphogen Gradients: How Important Are They for Growth?
Sci. Signal.,
October 27, 2009;
2(94):
pe67 - pe67.
[Abstract]
[Full Text]
[PDF]
L. A. Baena-Lopez, X. Franch-Marro, and J.-P. Vincent
Wingless Promotes Proliferative Growth in a Gradient-Independent Manner
Sci. Signal.,
October 6, 2009;
2(91):
ra60 - ra60.
[Abstract]
[Full Text]
[PDF]
E. Benitez, S. J. Bray, I. Rodriguez, and I. Guerrero
Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development
Development,
April 1, 2009;
136(7):
1211 - 1221.
[Abstract]
[Full Text]
[PDF]
G. Schwank, S. Restrepo, and K. Basler
Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels
Development,
December 15, 2008;
135(24):
4003 - 4013.
[Abstract]
[Full Text]
[PDF]
P. Hayward, T. Kalmar, and A. Martinez Arias
Wnt/Notch signalling and information processing during development
Development,
February 1, 2008;
135(3):
411 - 424.
[Abstract]
[Full Text]
[PDF]
M. Zecca and G. Struhl
Control of Drosophila wing growth by the vestigial quadrant enhancer
Development,
August 15, 2007;
134(16):
3011 - 3020.
[Abstract]
[Full Text]
[PDF]
© The Company of Biologists Ltd 2007