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Development ePress online publication date 1 Oct 2003
doi: 10.1242/dev.00762

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Research article

PP2A:B56{epsilon} is required for Wnt/{beta}-catenin signaling during embryonic development


Jing Yang, Jinling Wu, Change Tan, and Peter S. Klein*
* Author for correspondence (e-mail: pklein{at}mail.med.upenn.edu)

The Wnt/{beta}-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A) has been implicated as a regulator of this pathway. However, this has not been investigated by loss-of-function analyses. Here we report loss-of-function analysis of PP2A:B56{epsilon} during early Xenopus embryogenesis. We provide direct evidence that PP2A:B56{epsilon} is required for Wnt/{beta}-catenin signaling upstream of Dishevelled and downstream of the Wnt ligand. We show that maternal PP2A:B56{epsilon} function is required for dorsal development, and PP2A:B56{epsilon} function is required later for the expression of the Wnt target gene engrailed, for subsequent midbrain-hindbrain boundary formation, and for closure of the neural tube. These data demonstrate a positive role for PP2A:B56{epsilon} in the Wnt pathway.
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