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Development ePress online publication date 19 Nov 2003
doi: 10.1242/dev.00870

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Research article

Cadherin-mediated cell interaction regulates germ cell determination in mice


Daiji Okamura, Thoru Kimura, Toru Nakano, and Yasuhisa Matsui*
* Author for correspondence (e-mail: ymatsui{at}lab.mch.pref.osaka.jp)

The germ cell lineage segregates from the somatic cell lineages in early embryos. Germ cell determination in mice is not regulated by maternally inherited germplasm, but is initiated within the embryo during gastrulation. However, the mechanisms of germ cell specification in mice remain unknown. We located precursors to primordial germ cells (PGCs) within early embryos, and show here that cell-cell interaction among these precursors is required for germ cell specification. We found that the expression of a calcium-dependent cell adhesion molecule, E-cadherin, is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors, and that blocking the functions of E-cadherin with an antibody inhibits PGC formation in vitro. These results showed that E-cadherin-mediated cell-cell interaction among cells containing PGC precursors is essential to directing such cells to the germ cell fate.
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