The fully linked HTML version of this article has now been published.
Development ePress online publication date 26 Nov 2003
doi: 10.1242/dev.00896
Research article
Developmental origin of wiring specificity in the olfactory system of Drosophila
Gregory S. X. E. Jefferis,
Raj M. Vyas,
Daniela Berdnik,
Ariane Ramaekers,
Reinhard F. Stocker,
Nobuaki K. Tanaka,
Kei Ito,
and
Liqun Luo*
* Author for correspondence (e-mail: lluo{at}stanford.edu)
In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of 
50 glomeruli in the antennal lobe. How can a given class of ORN axons match up with a given class of PN dendrites? Here, we examine the cellular and developmental events that lead to this wiring specificity. We find that, before ORN axon arrival, PN dendrites have already created a prototypic map that resembles the adult glomerular map, by virtue of their selective dendritic localization. Positional cues that create this prototypic dendritic map do not appear to be either from the residual larval olfactory system or from glial processes within the antennal lobe. We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites.
This article has been cited by other articles:
|
|
|
|
 
P. Kain, T. S. Chakraborty, S. Sundaram, O. Siddiqi, V. Rodrigues, and G. Hasan
Reduced Odor Responses from Antennal Neurons of Gq{alpha}, Phospholipase C{beta}, and rdgA Mutants in Drosophila Support a Role for a Phospholipid Intermediate in Insect Olfactory Transduction
J. Neurosci.,
April 30, 2008;
28(18):
4745 - 4755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gerber and R. F. Stocker
The Drosophila Larva as a Model for Studying Chemosensation and Chemosensory Learning: A Review
Chem Senses,
January 1, 2007;
32(1):
65 - 89.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Berdnik, T. Chihara, A. Couto, and L. Luo
Wiring stability of the adult Drosophila olfactory circuit after lesion.
J. Neurosci.,
March 29, 2006;
26(13):
3367 - 3376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Ge, P. Krishnan, L. Liu, B. Krishnan, R. L. Davis, P. E. Hardin, and G. Roman
A Drosophila Nonvisual Arrestin Is Required for the Maintenance of Olfactory Sensitivity
Chem Senses,
January 1, 2006;
31(1):
49 - 62.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. C. Marin, R. J. Watts, N. K. Tanaka, K. Ito, and L. Luo
Developmentally programmed remodeling of the Drosophila olfactory circuit
Development,
February 15, 2005;
132(4):
725 - 737.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S.X.E. Jefferis, E. C. Marin, T. Komiyama, H. Zhu, T. Chihara, D. Berdnik, and L. Luo
Development of Wiring Specificity of the Drosophila Olfactory System
Chem Senses,
January 1, 2005;
30(suppl_1):
i94 - i94.
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2003
