spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 17 Dec 2003
doi: 10.1242/dev.00922


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.00922v1
131/2/435    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by da Graca, L. S.
Right arrow Articles by Patterson, G. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by da Graca, L. S.
Right arrow Articles by Patterson, G. I.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF{beta} pathway to regulate C. elegans dauer development


Li S. da Graca, Karen K. Zimmerman, Melissa C. Mitchell, Marianne Kozhan-Gorodetska, Kamila Sekiewicz, Yairani Morales, and Garth I. Patterson*
* Author for correspondence (e-mail: patterson{at}mbcl.rutgers.edu)

An unconventional TGF{beta} superfamily pathway plays a crucial role in the decision between dauer diapause and reproductive growth. We have studied the daf-5 gene, which, along with the daf-3 Smad gene, is antagonized by upstream receptors and receptor-regulated Smads. We show that DAF-5 is a novel member of the Sno/Ski superfamily that binds to DAF-3 Smad, suggesting that DAF-5, like Sno/Ski, is a regulator of transcription in a TGF{beta} superfamily signaling pathway. However, we present evidence that DAF-5 is an unconventional Sno/Ski protein, because DAF-5 acts as a co-factor, rather than an antagonist, of a Smad protein. We show that expressing DAF-5 in the nervous system rescues a daf-5 mutant, whereas muscle or hypodermal expression does not. Previous work suggested that DAF-5 and DAF-3 function in pharyngeal muscle to regulate gene expression, but our analysis of regulation of a pharynx specific promoter suggests otherwise. We present a model in which DAF-5 and DAF-3 control the production or release of a hormone from the nervous system by either regulating the expression of biosynthetic genes or by altering the connectivity or the differentiated state of neurons.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
GeneticsHome page
A. M. van der Linden, S. Wiener, Y.-j. You, K. Kim, L. Avery, and P. Sengupta
The EGL-4 PKG Acts With KIN-29 Salt-Inducible Kinase and Protein Kinase A to Regulate Chemoreceptor Gene Expression and Sensory Behaviors in Caenorhabditis elegans
Genetics, November 1, 2008; 180(3): 1475 - 1491.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
N. Fielenbach and A. Antebi
C. elegans dauer formation and the molecular basis of plasticity
Genes & Dev., August 15, 2008; 22(16): 2149 - 2165.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
T. Inoue, M. Ailion, S. Poon, H. K. Kim, J. H. Thomas, and P. W. Sternberg
Genetic Analysis of Dauer Formation in Caenorhabditis briggsae
Genetics, October 1, 2007; 177(2): 809 - 818.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
V. L. Jensen, P. S. Albert, and D. L. Riddle
Caenorhabditis elegans SDF-9 Enhances Insulin/Insulin-Like Signaling Through Interaction With DAF-2
Genetics, September 1, 2007; 177(1): 661 - 666.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. Nagano, K. J. Mavrakis, K. L. Lee, T. Fujii, D. Koinuma, H. Sase, K. Yuki, K. Isogaya, M. Saitoh, T. Imamura, et al.
Arkadia Induces Degradation of SnoN and c-Ski to Enhance Transforming Growth Factor-beta Signaling
J. Biol. Chem., July 13, 2007; 282(28): 20492 - 20501.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
E. Kodama, A. Kuhara, A. Mohri-Shiomi, K. D. Kimura, M. Okumura, M. Tomioka, Y. Iino, and I. Mori
Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.
Genes & Dev., November 1, 2006; 20(21): 2955 - 2960.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
N. T. Takaesu, C. Hyman-Walsh, Y. Ye, R. G. Wisotzkey, M. J. Stinchfield, M. B. O'Connor, D. Wotton, and S. J. Newfeld
dSno Facilitates Baboon Signaling in the Drosophila Brain by Switching the Affinity of Medea Away From Mad and Toward dSmad2
Genetics, November 1, 2006; 174(3): 1299 - 1313.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
Y. Wang and D. E. Levy
C. elegans STAT: evolution of a regulatory switch
FASEB J, August 1, 2006; 20(10): 1641 - 1652.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
E. Mizuhara, T. Nakatani, Y. Minaki, Y. Sakamoto, and Y. Ono
Corl1, a Novel Neuronal Lineage-specific Transcriptional Corepressor for the Homeodomain Transcription Factor Lbx1
J. Biol. Chem., February 4, 2005; 280(5): 3645 - 3655.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2003