spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 19 Dec 2007
doi: 10.1242/dev.010090


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.010090v1
135/3/493    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Griffin, C. T.
Right arrow Articles by Magnuson, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griffin, C. T.
Right arrow Articles by Magnuson, T.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development


Courtney T. Griffin, Jennifer Brennan, and Terry Magnuson*
* Author for correspondence (e-mail: terry magnuson{at}med.unc.edu)

ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also known as SMARCA4). We have conditionally deleted a floxed Brg1 allele with a Tie2-Cre transgene, which is expressed in developing hematopoietic and endothelial cells. Brg1fl/fl:Tie2-Cre+ embryos die at midgestation from anemia, as mutant primitive erythrocytes fail to transcribe embryonic {alpha}- and {beta}-globins, and subsequently undergo apoptosis. Additionally, vascular remodeling of the extraembryonic yolk sac is abnormal in Brg1fl/fl:Tie2-Cre+ embryos. Importantly, Brm deficiency does not exacerbate the erythropoietic or vascular abnormalities found in Brg1fl/fl:Tie2-Cre+ embryos, implying that Brg1-containing SWI/SNF-like complexes, rather than Brm-containing complexes, play a crucial role in primitive erythropoiesis and in early vascular development.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
DevelopmentHome page
G. D'Amico, D. T. Jones, E. Nye, K. Sapienza, A. R. Ramjuan, L. E. Reynolds, S. D. Robinson, V. Kostourou, D. Martinez, D. Aubyn, et al.
Regulation of lymphatic-blood vessel separation by endothelial Rac1
Development, December 1, 2009; 136(23): 4043 - 4053.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
S.-I. Kim, E. H. Bresnick, and S. J. Bultman
BRG1 directly regulates nucleosome structure and chromatin looping of the {alpha} globin locus to activate transcription
Nucleic Acids Res., October 1, 2009; 37(18): 6019 - 6027.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Flowers, N. G. Nagl Jr., G. R. Beck Jr., and E. Moran
Antagonistic Roles for BRM and BRG1 SWI/SNF Complexes in Differentiation
J. Biol. Chem., April 10, 2009; 284(15): 10067 - 10075.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. S. Kenneth, S. Mudie, P. van Uden, and S. Rocha
SWI/SNF Regulates the Cellular Response to Hypoxia
J. Biol. Chem., February 13, 2009; 284(7): 4123 - 4131.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
H. Shen, N. Powers, N. Saini, C. E.S. Comstock, A. Sharma, K. Weaver, M. P. Revelo, W. Gerald, E. Williams, W. J. Jessen, et al.
The SWI/SNF ATPase Brm Is a Gatekeeper of Proliferative Control in Prostate Cancer
Cancer Res., December 15, 2008; 68(24): 10154 - 10162.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
T. Sengupta, K. Chen, E. Milot, and J. J. Bieker
Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the {beta}-Globin Locus
Mol. Cell. Biol., October 15, 2008; 28(20): 6160 - 6170.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2007