spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 8 Apr 2004
doi: 10.1242/dev.01103

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01103v1
131/9/2173    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caillé, I.
Right arrow Articles by Prochiantz, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caillé, I.
Right arrow Articles by Prochiantz, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article: Development and disease

Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone


Isabelle Caillé, Bernadette Allinquant, Edmond Dupont, Colette Bouillot, Andreas Langer, Ulrike Müller, and Alain Prochiantz*
* Author for correspondence (e-mail: prochian{at}wotan.ens.fr)

The amyloid precursor protein (APP) is a type I transmembrane protein of unknown physiological function. Its soluble secreted form (sAPP) shows similarities with growth factors and increases the in vitro proliferation of embryonic neural stem cells. As neurogenesis is an ongoing process in the adult mammalian brain, we have investigated a role for sAPP in adult neurogenesis. We show that the subventricular zone (SVZ) of the lateral ventricle, the largest neurogenic area of the adult brain, is a major sAPP binding site and that binding occurs on progenitor cells expressing the EGF receptor. These EGF-responsive cells can be cultured as neurospheres (NS). In vitro, EGF provokes soluble APP (sAPP) secretion by NS and anti-APP antibodies antagonize the EGF-induced NS proliferation. In vivo, sAPP infusions increase the number of EGF-responsive progenitors through their increased proliferation. Conversely, blocking sAPP secretion or downregulating APP synthesis decreases the proliferation of EGF-responsive cells, which leads to a reduction of the pool of progenitors. These results reveal a new function for sAPP as a regulator of SVZ progenitor proliferation in the adult central nervous system.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. Thinakaran and E. H. Koo
Amyloid Precursor Protein Trafficking, Processing, and Function
J. Biol. Chem., October 31, 2008; 283(44): 29615 - 29619.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
E. Herczenik and M. F. B. G. Gebbink
Molecular and cellular aspects of protein misfolding and disease
FASEB J, July 1, 2008; 22(7): 2115 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Osterfield, R. Egelund, L. M. Young, and J. G. Flanagan
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system
Development, March 15, 2008; 135(6): 1189 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
P. A Riquelme, E. Drapeau, and F. Doetsch
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
Phil Trans R Soc B, January 12, 2008; 363(1489): 123 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Marutle, M. Ohmitsu, M. Nilbratt, N. H. Greig, A. Nordberg, and K. Sugaya
Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine
PNAS, July 24, 2007; 104(30): 12506 - 12511.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Ring, S. W. Weyer, S. B. Kilian, E. Waldron, C. U. Pietrzik, M. A. Filippov, J. Herms, C. Buchholz, C. B. Eckman, M. Korte, et al.
The Secreted {beta}-Amyloid Precursor Protein Ectodomain APPs{alpha} Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice
J. Neurosci., July 18, 2007; 27(29): 7817 - 7826.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. A. Drachman
Aging of the brain, entropy, and Alzheimer disease
Neurology, October 24, 2006; 67(8): 1340 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-L. Teo, H. Ma, C. Nguyen, C. Lam, and M. Kahn
Specific inhibition of CBP/{beta}-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation
PNAS, August 23, 2005; 102(34): 12171 - 12176.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
V. Palma, D. A. Lim, N. Dahmane, P. Sanchez, T. C. Brionne, C. D. Herzberg, Y. Gitton, A. Carleton, A. Alvarez-Buylla, and A. R. i Altaba
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
Development, January 15, 2005; 132(2): 335 - 344.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. D. Stein, N. J. Anders, C. DeCarli, S. L. Chan, M. P. Mattson, and J. A. Johnson
Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis
J. Neurosci., September 1, 2004; 24(35): 7707 - 7717.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004