spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 19 May 2004
doi: 10.1242/dev.01156

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01156v1
131/12/2853    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fürthauer, M.
Right arrow Articles by Thisse, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fürthauer, M.
Right arrow Articles by Thisse, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Fgf signalling controls the dorsoventral patterning of the zebrafish embryo


Maximilian Fürthauer, Jeanne Van Celst, Christine Thisse, and Bernard Thisse*
* Author for correspondence (e-mail: thisse{at}igbmc.u-strasbg.fr)

The establishment of dorsoventral (DV) patterning in vertebrate embryos depends on the morphogenic activity of a group of Tgf{beta} superfamily members, the bone morphogenetic proteins (Bmps) (which specify ventral cell fates), and on their interaction with their dorsally secreted cognate inhibitors chordin and noggin. In the zebrafish, genetic analysis has revealed that Bmp2b and Bmp7, as well as their antagonist chordin, are required for proper DV patterning. The expression of Bmp genes is initially activated in the whole blastula. Well before the beginning of gastrulation, Bmp gene expression progressively disappears from the dorsal side to become restricted to the ventral part of the embryo. We show that this early restriction of Bmp gene expression, which occurs independently of noggin and chordin, is an essential step in the establishment of DV patterning. The progressive ventral restriction of Bmp gene transcripts is coincident with the spreading of Fgf activity from the dorsal side of the embryo, suggesting that Fgf signalling is implicated in dorsal downregulation of Bmp gene expression. In accordance with this, activation of the Fgf/Ras/Mapk-signalling pathway inhibits ventral Bmp gene expression, thereby causing a dorsalisation of the embryo. Conversely, inhibition of Fgf signalling causes Bmp gene expression to expand dorsally, leading to an expansion of ventral cell fates. In accordance with an important role of Fgf signalling in the DV patterning of the zebrafish, we show that loss of Fgf8 function enhances the ventralisation of chordin-deficient embryos. Our results thereby demonstrate that pre-gastrula stage Fgf-signalling is essential to delimit the expression domain of the genes encoding the functional morphogen of the dorsoventral axis of the early zebrafish embryo.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
J.-D. Fauny, B. Thisse, and C. Thisse
The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity
Development, November 15, 2009; 136(22): 3811 - 3819.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Anastasaki, A. L. Estep, R. Marais, K. A. Rauen, and E. E. Patton
Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors
Hum. Mol. Genet., July 15, 2009; 18(14): 2543 - 2554.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. A. Gibby, K. McDonnell, M. O. Schmidt, and A. Wellstein
A distinct role for secreted fibroblast growth factor-binding proteins in development
PNAS, May 26, 2009; 106(21): 8585 - 8590.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kai, C.-P. Heisenberg, and M. Tada
Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation
Development, September 15, 2008; 135(18): 3043 - 3051.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Gaulden and J. F. Reiter
Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells
Hum. Mol. Genet., April 15, 2008; 17(R1): R60 - R66.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. M. Cotton, M. K. O'Bryan, and B. T. Hinton
Cellular Signaling by Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) in Male Reproduction
Endocr. Rev., April 1, 2008; 29(2): 193 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Ochi, S. Hans, and M. Westerfield
Smarcd3 Regulates the Timing of Zebrafish Myogenesis Onset
J. Biol. Chem., February 8, 2008; 283(6): 3529 - 3536.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Walmsley, D. Cleaver, and R. Patient
Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development
Blood, February 1, 2008; 111(3): 1157 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Chang and R. M. Harland
Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation
Development, November 1, 2007; 134(21): 3861 - 3872.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Yao, S. Nowak, A. Yochelis, A. Garfinkel, and K. I. Bostrom
Matrix GLA Protein, an Inhibitory Morphogen in Pulmonary Vascular Development
J. Biol. Chem., October 12, 2007; 282(41): 30131 - 30142.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Hans and M. Westerfield
Changes in retinoic acid signaling alter otic patterning
Development, July 1, 2007; 134(13): 2449 - 2458.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Nakazawa, H. Nagai, M. Shin, and G. Sheng
Negative regulation of primitive hematopoiesis by the FGF signaling pathway
Blood, November 15, 2006; 108(10): 3335 - 3343.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Q. Matus, K. Pang, H. Marlow, C. W. Dunn, G. H. Thomsen, and M. Q. Martindale
From the Cover: Molecular evidence for deep evolutionary roots of bilaterality in animal development
PNAS, July 25, 2006; 103(30): 11195 - 11200.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S. A. Holley
Anterior-posterior differences in vertebrate segments: specification of trunk and tail somites in the zebrafish blastula
Genes & Dev., July 15, 2006; 20(14): 1831 - 1837.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
D. P. Szeto and D. Kimelman
The regulation of mesodermal progenitor cell commitment to somitogenesis subdivides the zebrafish body musculature into distinct domains
Genes & Dev., July 15, 2006; 20(14): 1923 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Reim and M. Brand
Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4
Development, July 15, 2006; 133(14): 2757 - 2770.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. J. Machingo, A. Fritz, and B. D. Shur
A {beta}1,4-galactosyltransferase is required for Bmp2-dependent patterning of the dorsoventral axis during zebrafish embryogenesis
Development, June 1, 2006; 133(11): 2233 - 2241.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Poulain, M. Furthauer, B. Thisse, C. Thisse, and T. Lepage
Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling
Development, June 1, 2006; 133(11): 2189 - 2200.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. B. Fletcher, J. C. Baker, and R. M. Harland
FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in Xenopus
Development, May 1, 2006; 133(9): 1703 - 1714.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Gestri, M. Carl, I. Appolloni, S. W. Wilson, G. Barsacchi, and M. Andreazzoli
Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression
Development, May 15, 2005; 132(10): 2401 - 2413.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. D. Stern
Neural induction: old problem, new findings, yet more questions
Development, May 1, 2005; 132(9): 2007 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Rhinn, K. Lun, M. Luz, M. Werner, and M. Brand
Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling
Development, March 15, 2005; 132(6): 1261 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Delaune, P. Lemaire, and L. Kodjabachian
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
Development, January 15, 2005; 132(2): 299 - 310.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Kudoh, M. L. Concha, C. Houart, I. B. Dawid, and S. W. Wilson
Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
Development, August 1, 2004; 131(15): 3581 - 3592.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004