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Development ePress online publication date 26 May 2004
doi: 10.1242/dev.01158

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Research article

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues


Sylvaine Cases*, Ping Zhou, Jonathan M. Shillingford, Bryony S. Wiseman, Jo Dee Fish, Christina S. Angle, Lothar Hennighausen, Zena Werb, and Robert V. Farese Jr
* Author for correspondence (e-mail: scases{at}gladstone.ucsf.edu)

Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development.
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© The Company of Biologists Ltd 2004