spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 4 Aug 2004
doi: 10.1242/dev.01304

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01304v1
131/17/4371    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vokes, S. A.
Right arrow Articles by Krieg, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vokes, S. A.
Right arrow Articles by Krieg, P. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis


Steven A. Vokes, Tatiana A. Yatskievych, Ronald L. Heimark, Jill McMahon, Andrew P. McMahon, Parker B. Antin, and Paul A. Krieg*
* Author for correspondence (e-mail: pkrieg{at}email.arizona.edu)

During embryonic development, the first blood vessels are formed through the aggregation and subsequent assembly of angioblasts (endothelial precursors) into a network of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble into a vascular network and to undergo vascular tube formation. In this study, we show that endodermally derived sonic hedgehog is both necessary and sufficient for vascular tube formation in avian embryos. We also show that Hedgehog signaling is required for vascular tube formation in mouse embryos, and for vascular cord formation in cultured mouse endothelial cells. These results demonstrate a previously uncharacterized role for Hedgehog signaling in vascular development, and identify Hedgehog signaling as an important component of the molecular pathway leading to vascular tube formation.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
C. Lin, Y. Yin, G. M. Veith, A. V. Fisher, F. Long, and L. Ma
Temporal and spatial dissection of Shh signaling in genital tubercle development
Development, December 1, 2009; 136(23): 3959 - 3967.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S.-W. Jin and C. Patterson
The Opening Act: Vasculogenesis and the Origins of Circulation
Arterioscler Thromb Vasc Biol, May 1, 2009; 29(5): 623 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. R. Swift and B. M. Weinstein
Arterial-Venous Specification During Development
Circ. Res., March 13, 2009; 104(5): 576 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. J. Lavine and D. M. Ornitz
Shared Circuitry: Developmental Signaling Cascades Regulate Both Embryonic and Adult Coronary Vasculature
Circ. Res., January 30, 2009; 104(2): 159 - 169.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Kazanskaya, B. Ohkawara, M. Heroult, W. Wu, N. Maltry, H. G. Augustin, and C. Niehrs
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
Development, November 15, 2008; 135(22): 3655 - 3664.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Cao, L. Wang, D. Nandy, Y. Zhang, A. Basu, D. Radisky, and D. Mukhopadhyay
Neuropilin-1 Upholds Dedifferentiation and Propagation Phenotypes of Renal Cell Carcinoma Cells by Activating Akt and Sonic Hedgehog Axes
Cancer Res., November 1, 2008; 68(21): 8667 - 8672.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Sanchez-Camacho and P. Bovolenta
Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
Development, November 1, 2008; 135(21): 3531 - 3541.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Aitsebaomo, A. L. Portbury, J. C. Schisler, and C. Patterson
Brothers and Sisters: Molecular Insights Into Arterial-Venous Heterogeneity
Circ. Res., October 24, 2008; 103(9): 929 - 939.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. P. Mudumana, D. Hentschel, Y. Liu, A. Vasilyev, and I. A. Drummond
odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate
Development, October 15, 2008; 135(20): 3355 - 3367.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. J. Lavine, F. Long, K. Choi, C. Smith, and D. M. Ornitz
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
Development, September 15, 2008; 135(18): 3161 - 3171.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. C. Hong, T. Kume, and R. T. Peterson
Role of Crosstalk Between Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathways in Artery-Vein Specification
Circ. Res., September 12, 2008; 103(6): 573 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. N. Passman, X. R. Dong, S.-P. Wu, C. T. Maguire, K. A. Hogan, V. L. Bautch, and M. W. Majesky
A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells
PNAS, July 8, 2008; 105(27): 9349 - 9354.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
J. J. Zoeller, A. McQuillan, J. Whitelock, S.-Y. Ho, and R. V. Iozzo
A central function for perlecan in skeletal muscle and cardiovascular development
J. Cell Biol., April 21, 2008; 181(2): 381 - 394.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. A. Yoo, M. H. Kang, J. S. Kim, and S. C. Oh
Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-{beta}-mediated activation of the ALK5-Smad 3 pathway
Carcinogenesis, March 1, 2008; 29(3): 480 - 490.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Astorga and P. Carlsson
Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4
Development, October 15, 2007; 134(20): 3753 - 3761.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. C. White, K. J. Lavine, and D. M. Ornitz
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network
Development, October 15, 2007; 134(20): 3743 - 3752.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. Agouni, H. A. Mostefai, C. Porro, N. Carusio, J. Favre, V. Richard, D. Henrion, M. C. Martinez, and R. Andriantsitohaina
Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release
FASEB J, September 1, 2007; 21(11): 2735 - 2741.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Levenberg, J. Zoldan, Y. Basevitch, and R. Langer
Endothelial potential of human embryonic stem cells
Blood, August 1, 2007; 110(3): 806 - 814.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Schmidt, K. Brixius, and W. Bloch
Endothelial Precursor Cell Migration During Vasculogenesis
Circ. Res., July 20, 2007; 101(2): 125 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Hochman, A. Castiel, J. Jacob-Hirsch, N. Amariglio, and S. Izraeli
Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling
J. Biol. Chem., November 10, 2006; 281(45): 33860 - 33870.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. C. Martinez, F. Larbret, F. Zobairi, J. Coulombe, N. Debili, W. Vainchenker, M. Ruat, and J.-M. Freyssinet
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens
Blood, November 1, 2006; 108(9): 3012 - 3020.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
K. J. Lavine, A. C. White, C. Park, C. S. Smith, K. Choi, F. Long, C.-c. Hui, and D. M. Ornitz
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.
Genes & Dev., June 15, 2006; 20(12): 1651 - 1666.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Asai, H. Takenaka, K. F. Kusano, M. Ii, C. Luedemann, C. Curry, E. Eaton, A. Iwakura, Y. Tsutsumi, H. Hamada, et al.
Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell-Mediated Microvascular Remodeling
Circulation, May 23, 2006; 113(20): 2413 - 2424.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Z. Zhang, F. Cerrato, H. Xu, F. Vitelli, M. Morishima, J. Vincentz, Y. Furuta, L. Ma, J. F. Martin, A. Baldini, et al.
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
Development, December 1, 2005; 132(23): 5307 - 5315.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S.-W. Jin, D. Beis, T. Mitchell, J.-N. Chen, and D. Y. R. Stainier
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
Development, December 1, 2005; 132(23): 5199 - 5209.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. X. Liang, R. Summer, X. Sun, and A. Fine
Gene expression profiling and localization of Hoechst-effluxing CD45- and CD45+ cells in the embryonic mouse lung
Physiol Genomics, October 17, 2005; 23(2): 172 - 181.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Colnot, L. de la Fuente, S. Huang, D. Hu, C. Lu, B. St-Jacques, and J. A. Helms
Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
Development, March 1, 2005; 132(5): 1057 - 1067.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004