spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 1 Sep 2004
doi: 10.1242/dev.01337

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01337v1
131/19/4797    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haworth, K. E.
Right arrow Articles by Sharpe, P. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haworth, K. E.
Right arrow Articles by Sharpe, P. T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Regionalisation of early head ectoderm is regulated by endoderm and prepatterns the orofacial epithelium


Kim E. Haworth, Christopher Healy, Pamela Morgan, and Paul T. Sharpe*
* Author for correspondence (e-mail: paul.sharpe{at}kcl.ac.uk)

The oral epithelium becomes regionalised proximodistally early in development, and this is reflected by the spatial expression of signalling molecules such as Fgf8 and Bmp4. This regionalisation is responsible for regulating the spatial expression of genes in the underlying mesenchyme. These genes are required for the spatial patterning of bone, cartilage orofacial development and, in mammals, teeth. The mechanism and timing of this important regionalisation during head epithelium development are not known. Using lipophilic dyes to fate map the oral epithelium in chick embryos, we show that the cells that will occupy the epithelium of the distal and the proximal mandible primordium already occupy different spatial locations in the developing head ectoderm prior to the formation of the first pharyngeal arch and neural crest migration. Moreover, the ectoderm cells fated to become proximal oral epithelium express Fgf8 and this expression requires the presence of endoderm. Thus, the first fundamental patterning process in jaw morphogenesis is controlled by the early separation of specific areas of ectoderm that are regulated by ectoderm-endoderm interactions, and does not involve neural crest cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
F. Clauss, M.-C. Maniere, F. Obry, E. Waltmann, S. Hadj-Rabia, C. Bodemer, Y. Alembik, H. Lesot, and M. Schmittbuhl
Dento-Craniofacial Phenotypes and underlying Molecular Mechanisms in Hypohidrotic Ectodermal Dysplasia (HED): a Review
Journal of Dental Research, December 1, 2008; 87(12): 1089 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. M. Brito, M.-A. Teillet, and N. M. Le Douarin
Induction of mirror-image supernumerary jaws in chicken mandibular mesenchyme by Sonic Hedgehog-producing cells
Development, July 1, 2008; 135(13): 2311 - 2319.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Nair, W. Li, R. Cornell, and T. F. Schilling
Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
Development, January 15, 2007; 134(2): 335 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. M. Brito, M.-A. Teillet, and N. M. Le Douarin
An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival
PNAS, August 1, 2006; 103(31): 11607 - 11612.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. G. Crump, M. E. Swartz, J. K. Eberhart, and C. B. Kimmel
Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face
Development, July 15, 2006; 133(14): 2661 - 2669.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. A. Helms, D. Cordero, and M. D. Tapadia
New insights into craniofacial morphogenesis
Development, March 1, 2005; 132(5): 851 - 861.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004