spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 15 Sep 2004
doi: 10.1242/dev.01385

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01385v1
131/20/4921    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martín, F. A.
Right arrow Articles by Morata, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martín, F. A.
Right arrow Articles by Morata, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

The brinker gradient controls wing growth in Drosophila


Francisco A. Martín, Ainhoa Pérez-Garijo, Eduardo Moreno, and Ginés Morata*
* Author for correspondence (e-mail: gmorata{at}cbm.uam.es)

The Decapentaplegic (Dpp) morphogen gradient controls growth and patterning in the Drosophila appendages. There is recent evidence indicating that the Dpp gradient is converted into an inverse gradient of activity of the gene brinker (brk), which encodes a transcriptional repressor and is negatively regulated by the Dpp pathway. We have studied how alterations in the Brk gradient affect the growth of the wing disc. We find that there is a negative correlation between brk activity and growth of the disc: high levels of brk prevent or reduce growth, whereas loss of brk activity results in excessive growth. This effect is concentration dependent: different amounts of Brk produce distinct rates of growth. Furthermore, our results demonstrate that although brk is able to induce apoptosis where there is a sharp difference in Brk levels, its role as a growth repressor is not achieved by inducing apoptosis but by reducing cell proliferation. Brk appears to downregulate the activity of genes that control cell proliferation, such as bantam.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Sci SignalHome page
F. Hamaratoglu, K. Basler, and M. Affolter
Confronting Morphogen Gradients: How Important Are They for Growth?
Sci. Signal., October 27, 2009; 2(94): pe67 - pe67.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. M. McNamee and M. H. Brodsky
p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy
Genetics, June 1, 2009; 182(2): 423 - 435.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Perez-Garijo, E. Shlevkov, and G. Morata
The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
Development, April 1, 2009; 136(7): 1169 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Schwank, S. Restrepo, and K. Basler
Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels
Development, December 15, 2008; 135(24): 4003 - 4013.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. M. Tyler, W. Li, N. Zhuo, B. Pellock, and N. E. Baker
Genes Affecting Cell Competition in Drosophila
Genetics, February 1, 2007; 175(2): 643 - 657.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. A. Martin and G. Morata
Compartments and the control of growth in the Drosophila wing imaginal disc
Development, November 15, 2006; 133(22): 4421 - 4426.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. F. de Navas, D. L. Garaulet, and E. Sanchez-Herrero
The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway
Development, November 15, 2006; 133(22): 4495 - 4506.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. Dworkin and G. Gibson
Epidermal Growth Factor Receptor and Transforming Growth Factor-{beta} Signaling Contributes to Variation for Wing Shape in Drosophila melanogaster
Genetics, July 1, 2006; 173(3): 1417 - 1431.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Ren, B. He, D. Stone, S. Kirakodu, and P. N. Adler
The shavenoid Gene of Drosophila Encodes a Novel Actin Cytoskeleton Interacting Protein That Promotes Wing Hair Morphogenesis
Genetics, March 1, 2006; 172(3): 1643 - 1653.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Perez-Garijo, F. A. Martin, G. Struhl, and G. Morata
Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila
PNAS, December 6, 2005; 102(49): 17664 - 17669.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Ren, C. Zhu, H. Lee, and P. N. Adler
Gene Expression During Drosophila Wing Morphogenesis and Differentiation
Genetics, October 1, 2005; 171(2): 625 - 638.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. G. McEwen and M. Peifer
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis
Development, September 1, 2005; 132(17): 3935 - 3946.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Perez-Garijo, F. A. Martin, and G. Morata
Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila
Development, November 15, 2004; 131(22): 5591 - 5598.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004