Neural stem cells: balancing self-renewal with differentiation

doi:10.1242/dev.014977

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Development ePress online publication date 20 Mar 2008
doi: 10.1242/dev.014977

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Neural stem cells: balancing self-renewal with differentiation

Chris Q. Doe^*
^* Author for correspondence (e-mail: cdoe{at}uoregon.edu)

Stem cells are captivating because they have the potentialto make multiple cell types yet maintain their undifferentiatedstate. Recent studies of Drosophila and mammalian neural stemcells have shed light on how stem cells regulate self-renewalversus differentiation and have revealed the proteins, processesand pathways that all converge to regulate neural progenitorself-renewal. If we can better understand how stem cells balanceself-renewal versus differentiation, we will significantly advanceour knowledge of embryogenesis, cancer biology and brain evolution,as well as the use of stem cells for therapeutic purposes.

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