spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 17 Nov 2004
doi: 10.1242/dev.01530

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01530v1
131/24/6119    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tripodi, M.
Right arrow Articles by Studer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tripodi, M.
Right arrow Articles by Studer, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain


Marco Tripodi, Alessandro Filosa, Maria Armentano, and Michèle Studer*
* Author for correspondence (e-mail: studer{at}tigem.it)

Cells migrate via diverse pathways and in different modes to reach their final destinations during development. Tangential migration has been shown to contribute significantly to the generation of neuronal diversity in the mammalian telencephalon. GABAergic interneurons are the best-characterized neurons that migrate tangentially, from the ventral telencephalon, dorsally into the cortex. However, the molecular mechanisms and nature of these migratory pathways are only just beginning to be unravelled. In this study we have first identified a novel dorsal-to-ventral migratory route, in which cells migrate from the interganglionic sulcus, located in the basal telencephalon between the lateral and medial ganglionic eminences, towards the pre-optic area and anterior hypothalamus in the diencephalon. Next, with the help of transplantations and gain-of-function studies in organotypic cultures, we have shown that COUP-TFI and COUP-TFII are expressed in distinct and non-overlapping migratory routes. Ectopic expression of COUP-TFs induces an increased rate of cell migration and cell dispersal, suggesting roles in cellular adhesion and migration processes. Moreover, cells follow a distinct migratory path, dorsal versus ventral, which is dependent on the expression of COUP-TFI or COUP-TFII, suggesting an intrinsic role of COUP-TFs in guiding migrating neurons towards their target regions. Therefore, we propose that COUP-TFs are directly involved in tangential cell migration in the developing brain, through the regulation of short- and long-range guidance cues.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
J. F. Robinson, X. Yu, S. Hong, W. C. Griffith, R. Beyer, E. Kim, and E. M. Faustman
Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation
Toxicol. Sci., January 1, 2009; 107(1): 206 - 219.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Kanatani, M. Yozu, H. Tabata, and K. Nakajima
COUP-TFII Is Preferentially Expressed in the Caudal Ganglionic Eminence and Is Involved in the Caudal Migratory Stream
J. Neurosci., December 10, 2008; 28(50): 13582 - 13591.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. T. Fulp, G. Cho, E. D. Marsh, I. M. Nasrallah, P. A. Labosky, and J. A. Golden
Identification of Arx transcriptional targets in the developing basal forebrain
Hum. Mol. Genet., December 1, 2008; 17(23): 3740 - 3760.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. Batista-Brito, R. Machold, C. Klein, and G. Fishell
Gene Expression in Cortical Interneuron Precursors is Prescient of their Mature Function
Cereb Cortex, October 1, 2008; 18(10): 2306 - 2317.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. M. Kurrasch, C. C. Cheung, F. Y. Lee, P. V. Tran, K. Hata, and H. A. Ingraham
The Neonatal Ventromedial Hypothalamus Transcriptome Reveals Novel Markers with Spatially Distinct Patterning
J. Neurosci., December 12, 2007; 27(50): 13624 - 13634.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Armentano, A. Filosa, G. Andolfi, and M. Studer
COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth
Development, November 1, 2006; 133(21): 4151 - 4162.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. S. Tang, H. M. Alger, and F. A. Pereira
COUP-TFI controls Notch regulation of hair cell and support cell differentiation
Development, September 15, 2006; 133(18): 3683 - 3693.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Melkman and P. Sengupta
Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1
Development, April 15, 2005; 132(8): 1935 - 1949.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004