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Development ePress online publication date 10 Nov 2004
doi: 10.1242/dev.01532
Research article
3
1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development
Ralf S. Schmid,
Stephanie Shelton,
Amelia Stanco,
Yukako Yokota,
Jordan A. Kreidberg,
and
E. S. Anton*
* Author for correspondence (e-mail: anton{at}med.unc.edu)
We show that 
3 integrin mutation disrupts distinct aspects of neuronal migration and placement in the cerebral cortex. The preplate develops normally in 3 integrin mutant mice. However, time lapse imaging of migrating neurons in embryonic cortical slices indicates retarded radial and tangential migration of neurons, but not ventricular zone-directed migration. Examination of the actin cytoskeleton of 3 integrin mutant cortical cells reveals aberrant actin cytoskeletal dynamics at the leading edges. Deficits are also evident in the ability of developing neurons to probe their cellular environment with filopodial and lamellipodial activity. Calbindin or calretinin positive upper layer neurons as well as the deep layer neurons of 3 integrin mutant mice expressing EGFP were misplaced. These results suggest that 3
1 integrin deficiency impairs distinct patterns of neuronal migration and placement through dysregulated actin dynamics and defective ability to search and respond to migration modulating cues in the developing cortex.
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© The Company of Biologists Ltd 2004
