spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 19 Jan 2005
doi: 10.1242/dev.01601

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01601v1
132/4/817    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hahn, K. L.
Right arrow Articles by Wilson-Rawls, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hahn, K. L.
Right arrow Articles by Wilson-Rawls, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Lunatic fringe null female mice are infertile due to defects in meiotic maturation


Katherine L. Hahn, Joshua Johnson, Brian J. Beres, Sheena Howard, and Jeanne Wilson-Rawls*
* Author for correspondence (e-mail: nrawls{at}imap4.asu.edu)

We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of developing follicles. Lunatic fringe null female mice were found to be infertile. Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant folliculogenesis. Furthermore, oocytes from these mutants did not complete meiotic maturation. This is a novel observation because this is the first report describing a meiotic defect that results from mutations in genes that are expressed in the somatic granulosa cells and not the oocytes. This represents a new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol Hum ReprodHome page
C. Tingen, A. Kim, and T. K. Woodruff
The primordial pool of follicles and nest breakdown in mammalian ovaries
Mol. Hum. Reprod., December 1, 2009; 15(12): 795 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Kim, T. Nakajima, S. Hayashi, P. Chambon, H. Watanabe, T. Iguchi, and T. Sato
Effects of Diethylstilbestrol on Programmed Oocyte Death and Induction of Polyovular Follicles in Neonatal Mouse Ovaries
Biol Reprod, November 1, 2009; 81(5): 1002 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. A. Edson, A. K. Nagaraja, and M. M. Matzuk
The Mammalian Ovary from Genesis to Revelation
Endocr. Rev., October 1, 2009; 30(6): 624 - 712.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Trombly, T. K. Woodruff, and K. E. Mayo
Suppression of Notch Signaling in the Neonatal Mouse Ovary Decreases Primordial Follicle Formation
Endocrinology, February 1, 2009; 150(2): 1014 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
K L Hahn, B Beres, M. J Rowton, M K Skinner, Y Chang, A Rawls, and J Wilson-Rawls
A deficiency of lunatic fringe is associated with cystic dilation of the rete testis
Reproduction, January 1, 2009; 137(1): 79 - 93.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. A. Williams and P. Stanley
Mouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans
FASEB J, July 1, 2008; 22(7): 2273 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
W. Shen, L. Li, Z. Bai, Q. Pan, M. Ding, and H. Deng
In vitro development of mouse fetal germ cells into mature oocytes
Reproduction, August 1, 2007; 134(2): 223 - 231.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Chen, W. N. Jefferson, R. R. Newbold, E. Padilla-Banks, and M. E. Pepling
Estradiol, Progesterone, and Genistein Inhibit Oocyte Nest Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary in Vitro and in Vivo
Endocrinology, August 1, 2007; 148(8): 3580 - 3590.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Garcia-Rudaz, F. Luna, V. Tapia, B. Kerr, L. Colgin, F. Galimi, G. A. Dissen, N. D. Rawlings, and S. R. Ojeda
Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis
Development, March 1, 2007; 134(5): 945 - 957.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. Shen, D. Zhang, T. Qing, J. Cheng, Z. Bai, Y. Shi, M. Ding, and H. Deng
Live Offspring Produced by Mouse Oocytes Derived from Premeiotic Fetal Germ Cells
Biol Reprod, October 1, 2006; 75(4): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws
Ovarian follicle development and transgenic mouse models
Hum. Reprod. Update, September 1, 2006; 12(5): 537 - 555.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Xu, C. R. Norton, and T. Gridley
Not all lunatic fringe null female mice are infertile
Development, February 15, 2006; 133(4): 579 - 579.
[Full Text] [PDF]

Home page
 DevelopmentHome page
K. L. Hahn, J. Johnson, B. J. Beres, and J. Wilson-Rawls
A loss of lunatic fringe is associated with female infertility
Development, February 15, 2006; 133(4): 579 - 580.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Shi, M. Stahl, L. Lu, and P. Stanley
Canonical Notch Signaling Is Dispensable for Early Cell Fate Specifications in Mammals
Mol. Cell. Biol., November 1, 2005; 25(21): 9503 - 9508.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005