spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 12 Jan 2005
doi: 10.1242/dev.01610

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01610v1
132/4/713    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cox, V. T.
Right arrow Articles by Baylies, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cox, V. T.
Right arrow Articles by Baylies, M. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling


Virginia T. Cox and Mary K. Baylies*
* Author for correspondence (e-mail: m-baylies{at}ski.mskcc.org)

The patterning of the Drosophila mesoderm requires Wingless (Wg), one of the founding members of a large family of secreted glycoproteins, the Wnt family. Little is known about how Wg provides patterning information to the mesoderm, which is neither an epithelium nor contains the site of Wg production. By studying specification of muscle founder cells as marked by the lineage-specific transcription factor Slouch, we asked how mesodermal cells interpret the steady flow of Wg. Through the manipulation of place, time and amount of Wg signaling, we have observed that Slouch founder cell cluster II is more sensitive to Wg levels than the other Slouch-positive founder cell clusters. To specify Slouch cluster I, Wg signaling is required to maintain high levels of the myogenic transcriptional regulator Twist. However, to specify cluster II, Wg not only maintains high Twist levels, but also provides a second contribution to activate Slouch expression. This dual requirement for Wg provides a paradigm for understanding how one signaling pathway can act over time to create a diverse array of patterning outcomes.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
T. L. Lovato, M. M. Adams, P. W. Baker, and R. M. Cripps
A Molecular Mechanism of Temperature Sensitivity for Mutations Affecting the Drosophila Muscle Regulator Myocyte Enhancer Factor-2
Genetics, September 1, 2009; 183(1): 107 - 117.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. S. Jaramillo, C. V. Lovato, E. M. Baca, and R. M. Cripps
Crossveinless and the TGF{beta} pathway regulate fiber number in the Drosophila adult jump muscle
Development, April 1, 2009; 136(7): 1105 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Hayward, T. Kalmar, and A. Martinez Arias
Wnt/Notch signalling and information processing during development
Development, February 1, 2008; 135(3): 411 - 424.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. C. Lindsley, J. G. Gill, M. Kyba, T. L. Murphy, and K. M. Murphy
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm
Development, October 1, 2006; 133(19): 3787 - 3796.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005