spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 23 Feb 2005
doi: 10.1242/dev.01704

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01704v1
132/7/1487    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Satoh, A. K.
Right arrow Articles by Ready, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Satoh, A. K.
Right arrow Articles by Ready, D. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors


Akiko K. Satoh, Joseph E. O'Tousa, Koichi Ozaki, and Donald F. Ready*
* Author for correspondence (e-mail: dready{at}bilbo.bio.purdue.edu)

In developing Drosophila photoreceptors, rhodopsin is trafficked to the rhabdomere, a specialized domain within the apical membrane surface. Rab11, a small GTPase implicated in membrane traffic, immunolocalizes to the trans-Golgi network, cytoplasmic vesicles and tubules, and the base of rhabdomeres. One hour after release from the endoplasmic reticulum, rhodopsin colocalizes with Rab11 in vesicles at the base of the rhabdomere. When Rab11 activity is reduced by three different genetic procedures, rhabdomere morphogenesis is inhibited and rhodopsin-bearing vesicles proliferate within the cytosol. Rab11 activity is also essential for development of MVB endosomal compartments; this is probably a secondary consequence of impaired rhabdomere development. Furthermore, Rab11 is required for transport of TRP, another rhabdomeric protein, and for development of specialized membrane structures within Garland cells. These results establish a role for Rab11 in the post-Golgi transport of rhodopsin and of other proteins to the rhabdomeric membranes of photoreceptors, and in analogous transport processes in other cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
N. A. Bulgakova and E. Knust
The Crumbs complex: from epithelial-cell polarity to retinal degeneration
J. Cell Sci., August 1, 2009; 122(15): 2587 - 2596.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Gorska, Q. Liang, Z. Karim, and R. Alam
Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation
J. Immunol., August 1, 2009; 183(3): 1675 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
P. Raghu, E. Coessens, M. Manifava, P. Georgiev, T. Pettitt, E. Wood, I. Garcia-Murillas, H. Okkenhaug, D. Trivedi, Q. Zhang, et al.
Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels
J. Cell Biol., April 6, 2009; 185(1): 129 - 145.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
K. P. Harris and U. Tepass
Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis
J. Cell Biol., December 15, 2008; 183(6): 1129 - 1143.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Khandelwal, W. G. Ruiz, E. Balestreire-Hawryluk, O. A. Weisz, J. R. Goldenring, and G. Apodaca
Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells
PNAS, October 14, 2008; 105(41): 15773 - 15778.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Sato, B. D. Grant, A. Harada, and K. Sato
Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans
J. Cell Sci., October 1, 2008; 121(19): 3177 - 3186.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. J. Nilsen, S. Deininger, U. Nonstad, F. Skjeldal, H. Husebye, D. Rodionov, S. von Aulock, T. Hartung, E. Lien, O. Bakke, et al.
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36
J. Leukoc. Biol., July 1, 2008; 84(1): 280 - 291.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. A. Bulgakova, O. Kempkens, and E. Knust
Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila
J. Cell Sci., June 15, 2008; 121(12): 2018 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. I. Miura, J.-Y. Roignant, M. Wassef, and J. E. Treisman
Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor
Development, June 1, 2008; 135(11): 1913 - 1922.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. G. Giansanti, G. Belloni, and M. Gatti
Rab11 Is Required for Membrane Trafficking and Actomyosin Ring Constriction in Meiotic Cytokinesis of Drosophila Males
Mol. Biol. Cell, December 1, 2007; 18(12): 5034 - 5047.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Luo, Y. Wang, and G. Reiser
p24A, a Type I Transmembrane Protein, Controls ARF1-dependent Resensitization of Protease-activated Receptor-2 by Influence on Receptor Trafficking
J. Biol. Chem., October 12, 2007; 282(41): 30246 - 30255.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
O. Devergne, C. Ghiglione, and S. Noselli
The endocytic control of JAK/STAT signalling in Drosophila
J. Cell Sci., October 1, 2007; 120(19): 3457 - 3464.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Bogard, L. Lan, J. Xu, and R. S. Cohen
Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary
Development, October 1, 2007; 134(19): 3413 - 3418.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. T. Blankenship, M. T. Fuller, and J. A. Zallen
The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
J. Cell Sci., September 1, 2007; 120(17): 3099 - 3110.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Zhang, K. L. Schulze, P. R. Hiesinger, K. Suyama, S. Wang, M. Fish, M. Acar, R. A. Hoskins, H. J. Bellen, and M. P. Scott
Thirty-One Flavors of Drosophila Rab Proteins
Genetics, June 1, 2007; 176(2): 1307 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Simonsen, R. C. Cumming, K. Lindmo, V. Galaviz, S. Cheng, T. E. Rusten, and K. D. Finley
Genetic Modifiers of the Drosophila Blue Cheese Gene Link Defects in Lysosomal Transport With Decreased Life Span and Altered Ubiquitinated-Protein Profiles
Genetics, June 1, 2007; 176(2): 1283 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
B. X. Li, A. K. Satoh, and D. F. Ready
Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors
J. Cell Biol., May 21, 2007; 177(4): 659 - 669.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Khodosh, A. Augsburger, T. L. Schwarz, and P. A. Garrity
Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events
Development, December 1, 2006; 133(23): 4655 - 4665.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Liegeois, A. Benedetto, J.-M. Garnier, Y. Schwab, and M. Labouesse
The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans
J. Cell Biol., June 19, 2006; 173(6): 949 - 961.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Marois, A. Mahmoud, and S. Eaton
The endocytic pathway and formation of the Wingless morphogen gradient
Development, January 15, 2006; 133(2): 307 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. F. J. van de Graaf, Q. Chang, A. R. Mensenkamp, J. G. J. Hoenderop, and R. J. M. Bindels
Direct Interaction with Rab11a Targets the Epithelial Ca2+ Channels TRPV5 and TRPV6 to the Plasma Membrane
Mol. Cell. Biol., January 1, 2006; 26(1): 303 - 312.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Beronja, P. Laprise, O. Papoulas, M. Pellikka, J. Sisson, and U. Tepass
Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
J. Cell Biol., May 23, 2005; 169(4): 635 - 646.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005