spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 11 Jun 2008
doi: 10.1242/dev.019018

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.019018v1
135/14/2403    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andrechek, E. R.
Right arrow Articles by Nevins, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrechek, E. R.
Right arrow Articles by Nevins, J. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Patterns of cell signaling pathway activation that characterize mammary development


Eran R. Andrechek, Seiichi Mori, Rachel E. Rempel, Jeffrey T. Chang, and Joseph R. Nevins*
* Author for correspondence (e-mail: nevin001{at}mc.duke.edu)

Previous work has detailed the histological and biochemical changes associated with mammary development and remodeling. We have now made use of gene expression profiling, and in particular of the previously described signatures of cell signaling pathway activation, to explore the events associated with mammary gland development. We find that there is elevated E2F-specific pathway activity prior to lactation and relatively low levels of other important signaling pathways, such as RAS, MYC and SRC. Upon lactation and continuing into the involution phase, these patterns reverse with a dramatic increase in RAS, SRC and MYC pathway activity and a decline in E2F activity. At the end of involution, these patterns return to that of the adult non-lactating mammary gland. The importance of the changes in E2F pathway activity, particularly during the proliferative phase of mammary development, was confirmed through the analysis of mice deficient for various E2F proteins. Taken together, these results reveal a complex pattern of pathway activity in relation to the various phases of mammary gland development.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
E. R. Andrechek, R. D. Cardiff, J. T. Chang, M. L. Gatza, C. R. Acharya, A. Potti, and J. R. Nevins
Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential
PNAS, September 22, 2009; 106(38): 16387 - 16392.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. Medvedovic, R. Gear, J. M. Freudenberg, J. Schneider, R. Bornschein, M. Yan, M. J. Mistry, H. Hendrix, S. Karyala, D. Halbleib, et al.
Influence of fatty acid diets on gene expression in rat mammary epithelial cells
Physiol Genomics, June 10, 2009; 38(1): 80 - 88.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Sotgia, M. C. Casimiro, G. Bonuccelli, M. Liu, D. Whitaker-Menezes, O. Er, K. M. Daumer, I. Mercier, A. K. Witkiewicz, C. Minetti, et al.
Loss of Caveolin-3 Induces a Lactogenic Microenvironment that Is Protective Against Mammary Tumor Formation
Am. J. Pathol., February 1, 2009; 174(2): 613 - 629.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008