spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 6 Jul 2005
doi: 10.1242/dev.01919


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01919v1
132/15/3445    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kloc, M.
Right arrow Articles by Etkin, L. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kloc, M.
Right arrow Articles by Etkin, L. D.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Potential structural role of non-coding and coding RNAs in the organization of the cytoskeleton at the vegetal cortex of Xenopus oocytes


Malgorzata Kloc, Katarzyna Wilk, Diana Vargas, Yuri Shirato, Szczepan Bilinski, and Laurence D. Etkin*
* Author for correspondence (e-mail: lde{at}mdanderson.org)

The localization of RNA within a cell or embryo is crucial for proper cellular function or development. There is evidence that the cytoskeleton and RNA may function in the anchoring of localized RNAs at the vegetal cortex of Xenopus laevis oocytes. We found that the organization of the cytokeratin filaments but not the actin cytoskeleton depends on the presence of intact VegT mRNA and a noncoding RNA, Xlsirts. Destruction of either of these transcripts results in disruption of the cytokeratin cytoskeleton in a transcript-specific manner and interferes with proper formation of the germinal granules and subsequent development of the germline. Analysis of the distribution of endogenous VegT and Xlsirts in live oocytes using molecular beacons showed that these RNAs are integrated into the cytokeratin cytoskeleton. These results demonstrate a novel structural role of coding and noncoding RNAs in the organization of the vegetal cortex of Xenopus oocytes.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
DevelopmentHome page
T. N. Cuykendall and D. W. Houston
Vegetally localized Xenopus trim36 regulates cortical rotation and dorsal axis formation
Development, September 15, 2009; 136(18): 3057 - 3065.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
P. K. Arthur, M. Claussen, S. Koch, K. Tarbashevich, O. Jahn, and T. Pieler
Participation of Xenopus Elr-type Proteins in Vegetal mRNA Localization during Oogenesis
J. Biol. Chem., July 24, 2009; 284(30): 19982 - 19992.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
C. Cooper, J. Guo, Y. Yan, S. Chooniedass-Kothari, F. Hube, M. K. Hamedani, L. C. Murphy, Y. Myal, and E. Leygue
Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides
Nucleic Acids Res., July 1, 2009; 37(13): 4518 - 4531.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
J. E. Wilusz, H. Sunwoo, and D. L. Spector
Long noncoding RNAs: functional surprises from the RNA world
Genes & Dev., July 1, 2009; 23(13): 1494 - 1504.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. T. F. Sasaki, T. Ideue, M. Sano, T. Mituyama, and T. Hirose
MEN{varepsilon}/{beta} noncoding RNAs are essential for structural integrity of nuclear paraspeckles
PNAS, February 24, 2009; 106(8): 2525 - 2530.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
G. Condorelli and S. Dimmeler
MicroRNAs: components of an integrated system controlling cardiac development, physiology, and disease pathogenesis
Cardiovasc Res, September 1, 2008; 79(4): 551 - 552.
[Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
L.-h. Meng, Z. Meng, Z.-h. Miao, T. D. Veenstra, and Y. Pommier
Cytokeratin-RNA Cross-Linking Mediated by the Antitumor Aminoflavone, 5-Amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
J. Pharmacol. Exp. Ther., May 1, 2008; 325(2): 674 - 680.
[Abstract] [Full Text] [PDF]


Home page
Sci SignalHome page
W. O'Gorman and A. Akoulitchev
What Is So Special About Oskar Wild?
Sci. Signal., December 12, 2006; 2006(365): pe51 - pe51.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Jenny, O. Hachet, P. Zavorszky, A. Cyrklaff, M. D. J. Weston, D. S. Johnston, M. Erdelyi, and A. Ephrussi
A translation-independent role of oskar RNA in early Drosophila oogenesis
Development, August 1, 2006; 133(15): 2827 - 2833.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J. Heasman
Patterning the early Xenopus embryo.
Development, April 1, 2006; 133(7): 1205 - 1217.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
K. CZAPLINSKI and I. W. MATTAJ
40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-Localization Element
RNA, February 1, 2006; 12(2): 213 - 222.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2005