spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 20 Jul 2005
doi: 10.1242/dev.01941

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01941v1
132/16/3691    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cebrià, F.
Right arrow Articles by Newmark, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cebrià, F.
Right arrow Articles by Newmark, P. A.

Research article

Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture


Francesc Cebrià and Phillip A. Newmark*
* Author for correspondence (e-mail: pnewmark{at}life.uiuc.edu)

Conserved axon guidance mechanisms are essential for proper wiring of the nervous system during embryogenesis; however, the functions of these cues in adults and during regeneration remain poorly understood. Because freshwater planarians can regenerate a functional central nervous system (CNS) from almost any portion of their body, they are useful models in which to study the roles of guidance cues during neural regeneration. Here, we characterize two netrin homologs and one netrin receptor family member from Schmidtea mediterranea. RNAi analyses indicate that Smed-netR (netrin receptor) and Smed-netrin2 are required for proper CNS regeneration and that Smed-netR may mediate the response to Smed-netrin2. Remarkably, Smed-netR and Smed-netrin2 are also required in intact planarians to maintain the proper patterning of the CNS. These results suggest a crucial role for guidance cues, not only in CNS regeneration but also in maintenance of neural architecture.


This article has been cited by other articles:


Home page
 CSH ProtocolsHome page
N. J. Oviedo, C. L. Nicolas, D. S. Adams, and M. Levin
Establishing and Maintaining a Colony of Planarians
CSH Protocols, October 1, 2008; 2008(11): pdb.prot5053 - pdb.prot5053.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
A. A. Wills, A. R. Kidd III, A. Lepilina, and K. D. Poss
Fgfs control homeostatic regeneration in adult zebrafish fins
Development, September 15, 2008; 135(18): 3063 - 3070.
[Abstract] [Full Text] [PDF]

Home page
 DMMHome page
N. J. Oviedo, B. J. Pearson, M. Levin, and A. Sanchez Alvarado
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
Dis. Model. Mech., September 1, 2008; 1(2-3): 131 - 143.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
D. Palakodeti, M. Smielewska, Y.-C. Lu, G. W. Yeo, and B. R. Graveley
The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians
RNA, June 1, 2008; 14(6): 1174 - 1186.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Iglesias, J. L. Gomez-Skarmeta, E. Salo, and T. Adell
Silencing of Smed-{beta}catenin1 generates radial-like hypercephalized planarians
Development, April 1, 2008; 135(7): 1215 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. J. Oviedo and M. Levin
smedinx-11 is a planarian stem cell gap junction gene required for regeneration and homeostasis
Development, September 1, 2007; 134(17): 3121 - 3131.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Inoue, T. Hayashi, K. Takechi, and K. Agata
Clathrin-mediated endocytic signals are required for the regeneration of, as well as homeostasis in, the planarian CNS
Development, May 1, 2007; 134(9): 1679 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wang, R. M. Zayas, T. Guo, and P. A. Newmark
nanos function is essential for development and regeneration of planarian germ cells
PNAS, April 3, 2007; 104(14): 5901 - 5906.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Cebria and P. A. Newmark
Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians
Development, March 1, 2007; 134(5): 833 - 837.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. D. Wilson, M. Ii, K. W. Park, A. Suli, L. K. Sorensen, F. Larrieu-Lahargue, L. D. Urness, W. Suh, J. Asai, G. A.H. Kock, et al.
Netrins Promote Developmental and Therapeutic Angiogenesis
Science, August 4, 2006; 313(5787): 640 - 644.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
E. Fusaoka, T. Inoue, K. Mineta, K. Agata, and K. Takeuchi
Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian
Genes Cells, May 1, 2006; 11(5): 541 - 555.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005