spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 3 Aug 2005
doi: 10.1242/dev.01966

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.01966v1
132/17/3923    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sternlicht, M. D.
Right arrow Articles by Werb, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sternlicht, M. D.
Right arrow Articles by Werb, Z.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin


Mark D. Sternlicht*, Susan W. Sunnarborg, Hosein Kouros-Mehr, Ying Yu, David C. Lee, and Zena Werb
* Author for correspondence (e-mail: sternli{at}itsa.ucsf.edu)

Epithelial-mesenchymal crosstalk is essential for tissue morphogenesis, but incompletely understood. Postnatal mammary gland development requires epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved from its transmembrane form in order to function. As the transmembrane metalloproteinase ADAM17 can process AREG in culture and Adam17-/- mice tend to phenocopy Egfr-/- mice, we examined the role of each of these molecules in mammary development. Tissue recombination and transplantation studies revealed that EGFR phosphorylation and ductal development occur only when ADAM17 and AREG are expressed on mammary epithelial cells, whereas EGFR is required stromally, and that local AREG administration can rescue Adam17-/- transplants. Several EGFR agonists also stimulated Adam17-/- mammary organoid growth in culture, but only AREG was expressed abundantly in the developing ductal system in vivo. Thus, ADAM17 plays a crucial role in mammary morphogenesis by releasing AREG from mammary epithelial cells, thereby eliciting paracrine activation of stromal EGFR and reciprocal responses that regulate mammary epithelial development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
W. B. Melenhorst, L. Visser, A. Timmer, M. C. van den Heuvel, C. A. Stegeman, and H. van Goor
ADAM17 upregulation in human renal disease: a role in modulating TGF-{alpha} availability?
Am J Physiol Renal Physiol, September 1, 2009; 297(3): F781 - F790.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Yao, W. Zhou, S. T. Lee-Hoeflich, T. Truong, P. M. Haverty, J. Eastham-Anderson, N. Lewin-Koh, B. Gunter, M. Belvin, L. J. Murray, et al.
Suppression of HER2/HER3-Mediated Growth of Breast Cancer Cells with Combinations of GDC-0941 PI3K Inhibitor, Trastuzumab, and Pertuzumab
Clin. Cancer Res., June 15, 2009; 15(12): 4147 - 4156.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. M. Le Gall, P. Bobe, K. Reiss, K. Horiuchi, X.-D. Niu, D. Lundell, D. R. Gibb, D. Conrad, P. Saftig, and C. P. Blobel
ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor {alpha}, L-Selectin, and Tumor Necrosis Factor {alpha}
Mol. Biol. Cell, March 15, 2009; 20(6): 1785 - 1794.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. L. Kleinberg, T. L. Wood, P. A. Furth, and A. V. Lee
Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions
Endocr. Rev., February 1, 2009; 30(1): 51 - 74.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. W. Gelling, W. Yan, S. Al-Noori, A. Pardini, G. J. Morton, K. Ogimoto, M. W. Schwartz, and P. J. Dempsey
Deficiency of TNF{alpha} Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice
Endocrinology, December 1, 2008; 149(12): 6053 - 6064.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
W. P. Daley, S. B. Peters, and M. Larsen
Extracellular matrix dynamics in development and regenerative medicine
J. Cell Sci., February 1, 2008; 121(3): 255 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Ali and V. Knauper
Phorbol Ester-induced Shedding of the Prostate Cancer Marker Transmembrane Protein with Epidermal Growth Factor and Two Follistatin Motifs 2 Is Mediated by the Disintegrin and Metalloproteinase-17
J. Biol. Chem., December 28, 2007; 282(52): 37378 - 37388.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
K. Britt, A. Ashworth, and M. Smalley
Pregnancy and the risk of breast cancer
Endocr. Relat. Cancer, December 1, 2007; 14(4): 907 - 933.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. L. Streicher, N. E. Willmarth, J. Garcia, J. L. Boerner, T. G. Dewey, and S. P. Ethier
Activation of a Nuclear Factor {kappa}B/Interleukin-1 Positive Feedback Loop by Amphiregulin in Human Breast Cancer Cells
Mol. Cancer Res., August 1, 2007; 5(8): 847 - 861.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al.
Estrogen Receptors: How Do They Signal and What Are Their Targets
Physiol Rev, July 1, 2007; 87(3): 905 - 931.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Horwitz, E. B. Affar, G. F. Heine, Y. Shi, and J. D. Parvin
A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase
PNAS, April 17, 2007; 104(16): 6614 - 6619.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Ciarloni, S. Mallepell, and C. Brisken
Amphiregulin is an essential mediator of estrogen receptor {alpha} function in mammary gland development
PNAS, March 27, 2007; 104(13): 5455 - 5460.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Kawaguchi, K. Horiuchi, J. D. Becherer, Y. Toyama, P. Besmer, and C. P. Blobel
Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19
J. Cell Sci., March 15, 2007; 120(6): 943 - 952.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. V. Hojilla, I. Kim, Z. Kassiri, J. E. Fata, H. Fang, and R. Khokha
Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3
J. Cell Sci., March 15, 2007; 120(6): 1050 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. Horiuchi, S. Le Gall, M. Schulte, T. Yamaguchi, K. Reiss, G. Murphy, Y. Toyama, D. Hartmann, P. Saftig, and C. P. Blobel
Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx
Mol. Biol. Cell, January 1, 2007; 18(1): 176 - 188.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. E. Willmarth and S. P. Ethier
Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells
J. Biol. Chem., December 8, 2006; 281(49): 37728 - 37737.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Ohtsu, P. J. Dempsey, and S. Eguchi
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C1 - C10.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
C L Wilson, A H Sims, A Howell, C J Miller, and R B Clarke
Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue.
Endocr. Relat. Cancer, June 1, 2006; 13(2): 617 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Mallepell, A.ée Krust, P. Chambon, and C. Brisken
Paracrine signaling through the epithelial estrogen receptor {alpha} is required for proliferation and morphogenesis in the mammary gland
PNAS, February 14, 2006; 103(7): 2196 - 2201.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005