spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 24 Aug 2005
doi: 10.1242/dev.02007

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02007v1
132/19/4223    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muriel, J. M.
Right arrow Articles by Vogel, B. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muriel, J. M.
Right arrow Articles by Vogel, B. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner


Joaquin M. Muriel, Chun Dong, Harald Hutter, and Bruce E. Vogel*
* Author for correspondence (e-mail: vogel{at}umbi.umd.edu)

Fibulins are a family of extracellular glycoproteins associated with basement membranes and elastic fibers in vertebrates. Conservation of the fibulin-1 gene throughout metazoan evolution includes fibulin-1C and fibulin-1D alternate splice variants, although little is known about variant specific functions that would justify this striking structural conservation. We have therefore investigated the structure, localization and loss-of-function phenotype specific to both fibulin-1 variants in C. elegans. We find that fibulin-1C has specific roles during pharynx, intestine, gonad and muscle morphogenesis, being required to regulate cell shape and adhesion, whereas fibulin-1D assembles in flexible polymers that connect the pharynx and body-wall-muscle basement membranes. The assembly of fibulin-1C and fibulin-1D in multiple locations is dependent upon the presence of hemicentin, a recently described extracellular member of the immunoglobulin superfamily. We suggest that the distinct developmental roles and hemicentin-dependent assembly for fibulin-1 splice variants demonstrated here may be relevant to fibulin-1 and possibly other fibulin family members in non-nematode species.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H. S. Courtney, Y. Li, W. O. Twal, and W. S. Argraves
Serum Opacity Factor Is a Streptococcal Receptor for the Extracellular Matrix Protein Fibulin-1
J. Biol. Chem., May 8, 2009; 284(19): 12966 - 12971.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Trzebiatowska, U. Topf, U. Sauder, K. Drabikowski, and R. Chiquet-Ehrismann
Caenorhabditis elegans Teneurin, ten-1, Is Required for Gonadal and Pharyngeal Basement Membrane Integrity and Acts Redundantly with Integrin ina-1 and Dystroglycan dgn-1
Mol. Biol. Cell, September 1, 2008; 19(9): 3898 - 3908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C.-H. Yi, D. J. Smith, W. W. West, and M. A. Hollingsworth
Loss of Fibulin-2 Expression Is Associated with Breast Cancer Progression
Am. J. Pathol., May 1, 2007; 170(5): 1535 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
X. Xu, C. Dong, and B. E. Vogel
Hemicentins Assemble on Diverse Epithelia in the Mouse
J. Histochem. Cytochem., February 1, 2007; 55(2): 119 - 126.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
D. Hesselson and J. Kimble
Growth control by EGF repeats of the C. elegans Fibulin-1C isoform
J. Cell Biol., October 23, 2006; 175(2): 217 - 223.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Dong, J. M. Muriel, S. Ramirez, H. Hutter, E. M. Hedgecock, L. Breydo, I. V. Baskakov, and B. E. Vogel
Hemicentin Assembly in the Extracellular Matrix Is Mediated by Distinct Structural Modules
J. Biol. Chem., August 18, 2006; 281(33): 23606 - 23610.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005