spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 16 Nov 2005
doi: 10.1242/dev.02167

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02167v1
132/24/5461    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Glasgow, S. M.
Right arrow Articles by Johnson, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glasgow, S. M.
Right arrow Articles by Johnson, J. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn


Stacey M. Glasgow, R. Michael Henke, Raymond J. MacDonald, Christopher V.E. Wright, and Jane E. Johnson*
* Author for correspondence (e-mail: jane.johnson{at}utsouthwestern.edu)

Mutations in the human and mouse PTF1A/Ptf1a genes result in permanent diabetes mellitus and cerebellar agenesis. We show that Ptf1a is present in precursors to GABAergic neurons in spinal cord dorsal horn as well as the cerebellum. A null mutation in Ptf1a reveals its requirement for the dorsal horn GABAergic neurons. Specifically, Ptf1a is required for the generation of early-born (dI4, E10.5) and late-born (dILA, E12.5) dorsal interneuron populations identified by homeodomain factors Lhx1/5 and Pax2. Furthermore, in the absence of Ptf1a, the dI4 dorsal interneurons trans-fate to dI5 (Lmx1b+), and the dILA to dILB (Lmx1b+;Tlx3+). This mis-specification of neurons results in a complete loss of inhibitory GABAergic neurons and an increase in the excitatory glutamatergic neurons in the dorsal horn of the spinal cord by E16.5. Thus, Ptf1a function is essential for GABAergic over glutamatergic neuronal cell fates in the developing spinal cord, and provides an important genetic link between inhibitory and excitatory interneuron development.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Scholpp, A. Delogu, J. Gilthorpe, D. Peukert, S. Schindler, and A. Lumsden
Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus
PNAS, November 24, 2009; 106(47): 19895 - 19900.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. J. Barkovich, K. J. Millen, and W. B. Dobyns
A developmental and genetic classification for midbrain-hindbrain malformations
Brain, November 20, 2009; (2009) awp247v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. M. Meredith, T. Masui, G. H. Swift, R. J. MacDonald, and J. E. Johnson
Multiple Transcriptional Mechanisms Control Ptf1a Levels during Neural Development Including Autoregulation by the PTF1-J Complex
J. Neurosci., September 9, 2009; 29(36): 11139 - 11148.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. M. Henke, T. K. Savage, D. M. Meredith, S. M. Glasgow, K. Hori, J. Dumas, R. J. MacDonald, and J. E. Johnson
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord
Development, September 1, 2009; 136(17): 2945 - 2954.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. J. Pernia-Andrade, A. Kato, R. Witschi, R. Nyilas, I. Katona, T. F. Freund, M. Watanabe, J. Filitz, W. Koppert, J. Schuttler, et al.
Spinal Endocannabinoids and CB1 Receptors Mediate C-Fiber-Induced Heterosynaptic Pain Sensitization
Science, August 7, 2009; 325(5941): 760 - 764.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Fujiyama, M. Yamada, M. Terao, T. Terashima, H. Hioki, Y. U. Inoue, T. Inoue, N. Masuyama, K. Obata, Y. Yanagawa, et al.
Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
Development, June 15, 2009; 136(12): 2049 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Storm, J. Cholewa-Waclaw, K. Reuter, D. Brohl, M. Sieber, M. Treier, T. Muller, and C. Birchmeier
The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei
Development, January 15, 2009; 136(2): 295 - 305.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Kala, M. Haugas, K. Lillevali, J. Guimera, W. Wurst, M. Salminen, and J. Partanen
Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons
Development, January 15, 2009; 136(2): 253 - 262.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Liu, H. Li, X. Hu, L. Yu, H. Liu, R. Han, R. Colella, G. D. Mower, Y. Chen, and M. Qiu
Control of Precerebellar Neuron Development by Olig3 bHLH Transcription Factor
J. Neurosci., October 1, 2008; 28(40): 10124 - 10133.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Masui, G. H. Swift, M. A. Hale, D. M. Meredith, J. E. Johnson, and R. J. MacDonald
Transcriptional Autoregulation Controls Pancreatic Ptf1a Expression during Development and Adulthood
Mol. Cell. Biol., September 1, 2008; 28(17): 5458 - 5468.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Cau, A. Quillien, and P. Blader
Notch resolves mixed neural identities in the zebrafish epiphysis
Development, July 15, 2008; 135(14): 2391 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Xu, C. Lopes, Y. Qian, Y. Liu, L. Cheng, M. Goulding, E. E. Turner, D. Lima, and Q. Ma
Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons
J. Neurosci., April 9, 2008; 28(15): 4037 - 4046.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
K. Hori, J. Cholewa-Waclaw, Y. Nakada, S. M. Glasgow, T. Masui, R. M. Henke, H. Wildner, B. Martarelli, T. M. Beres, J. A. Epstein, et al.
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling
Genes & Dev., January 15, 2008; 22(2): 166 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. A. Aldinger and G. E. Elsen
Ptf1a Is a Molecular Determinant for Both Glutamatergic and GABAergic Neurons in the Hindbrain
J. Neurosci., January 9, 2008; 28(2): 338 - 339.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
T. Masui, Q. Long, T. M. Beres, M. A. Magnuson, and R. J. MacDonald
Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
Genes & Dev., October 15, 2007; 21(20): 2629 - 2643.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Yamada, M. Terao, T. Terashima, T. Fujiyama, Y. Kawaguchi, Y.-i. Nabeshima, and M. Hoshino
Origin of Climbing Fiber Neurons and Their Developmental Dependence on Ptf1a
J. Neurosci., October 10, 2007; 27(41): 10924 - 10934.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Zhao, K.-M. Kwan, C. M. Mailloux, W.-K. Lee, A. Grinberg, W. Wurst, R. R. Behringer, and H. Westphal
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum
PNAS, August 7, 2007; 104(32): 13182 - 13186.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Nakatani, Y. Minaki, M. Kumai, and Y. Ono
Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon
Development, August 1, 2007; 134(15): 2783 - 2793.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. O. Wiebe, J. D. Kormish, V. T. Roper, Y. Fujitani, N. I. Alston, K. S. Zaret, C. V. E. Wright, R. W. Stein, and M. Gannon
Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-Wide Pdx1 Expression
Mol. Cell. Biol., June 1, 2007; 27(11): 4093 - 4104.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Pascual, I. Abasolo, A. Mingorance-Le Meur, A. Martinez, J. A. Del Rio, C. V. E. Wright, F. X. Real, and E. Soriano
Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
PNAS, March 20, 2007; 104(12): 5193 - 5198.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Nakhai, S. Sel, J. Favor, L. Mendoza-Torres, F. Paulsen, G. I. W. Duncker, and R. M. Schmid
Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina
Development, March 15, 2007; 134(6): 1151 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Pillai, A. Mansouri, R. Behringer, H. Westphal, and M. Goulding
Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord
Development, January 15, 2007; 134(2): 357 - 366.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Fujitani, S. Fujitani, H. Luo, F. Qiu, J. Burlison, Q. Long, Y. Kawaguchi, H. Edlund, R. J. MacDonald, T. Furukawa, et al.
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.
Development, November 1, 2006; 133(22): 4439 - 4450.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Q. Ma
Transcriptional regulation of neuronal phenotype in mammals
J. Physiol., September 1, 2006; 575(2): 379 - 387.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
H. Wildner, T. Muller, S.-H. Cho, D. Brohl, C. L. Cepko, F. Guillemot, and C. Birchmeier
dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development
Development, June 1, 2006; 133(11): 2105 - 2113.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005