The fully linked HTML version of this article has now been published.
Development ePress online publication date 1 Feb 2006
doi: 10.1242/dev.02271
Research article
Wnt signals mediate a fate decision between otic placode and epidermis
Takahiro Ohyama,
Othman A. Mohamed,
Makoto M. Taketo,
Daniel Dufort,
and
Andrew K. Groves*
* Author for correspondence (e-mail: agroves{at}hei.org)
The otic placode, the anlagen of the inner ear, develops from an ectodermal field characterized by expression of the transcription factor Pax2. Previous fate mapping studies suggest that these Pax2+ cells will give rise to both otic placode tissue and epidermis, but the signals that divide the Pax2+ field into placodal and epidermal territories are unknown. We report that Wnt signaling is normally activated in a subset of Pax2+ cells, and that conditional inactivation of 
-catenin in these cells causes an expansion of epidermal markers at the expense of the otic placode. Conversely, conditional activation of -catenin in Pax2+ cells causes an expansion of the otic placode at the expense of epidermis, and the resulting otic tissue expresses exclusively dorsal otocyst markers. Together, these results suggest that Wnt signaling acts instructively to direct Pax2+ cells to an otic placodal, rather than an epidermal, fate and promotes dorsal cell identities in the otocyst.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Dabdoub, C. Puligilla, J. M. Jones, B. Fritzsch, K. S. E. Cheah, L. H. Pevny, and M. W. Kelley
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
PNAS,
November 25, 2008;
105(47):
18396 - 18401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Freter, Y. Muta, S.-S. Mak, S. Rinkwitz, and R. K. Ladher
Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential
Development,
October 15, 2008;
135(20):
3415 - 3424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice
Genes & Dev.,
September 1, 2008;
22(17):
2308 - 2341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Jayasena, T. Ohyama, N. Segil, and A. K. Groves
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
Development,
July 1, 2008;
135(13):
2251 - 2261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Barembaum and M. Bronner-Fraser
Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm
Development,
November 1, 2007;
134(21):
3805 - 3814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P. Hatch, C. A. Noyes, X. Wang, T. J. Wright, and S. L. Mansour
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
Development,
October 15, 2007;
134(20):
3615 - 3625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Sajan, M. E. Warchol, and M. Lovett
Toward a Systems Biology of Mouse Inner Ear Organogenesis: Gene Expression Pathways, Patterns and Network Analysis
Genetics,
September 1, 2007;
177(1):
631 - 653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Iglesias, P.-A. Hueber, L. Chu, R. Campbell, A.-M. Patenaude, A. J. Dziarmaga, J. Quinlan, O. Mohamed, D. Dufort, and P. R. Goodyer
Canonical WNT signaling during kidney development
Am J Physiol Renal Physiol,
August 1, 2007;
293(2):
F494 - F500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hans and M. Westerfield
Changes in retinoic acid signaling alter otic patterning
Development,
July 1, 2007;
134(13):
2449 - 2458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nechiporuk, T. Linbo, K. D. Poss, and D. W. Raible
Specification of epibranchial placodes in zebrafish
Development,
February 1, 2007;
134(3):
611 - 623.
[Abstract]
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2006
