The fully linked HTML version of this article has now been published.
Development ePress online publication date 8 Feb 2006
doi: 10.1242/dev.02274
Research article
Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
Wataru Satoh,
Takafumi Gotoh,
Yasuhiko Tsunematsu,
Shinichi Aizawa,
and
Akihiko Shimono*
* Author for correspondence (e-mail: ashimono{at}cdb.riken.jp)
Regulation of Wnt signaling is essential for embryonic patterning. Sfrps are secreted Wnt antagonists that directly interact with the Wnt ligand to inhibit signaling. Here, we show that Sfrp1 and Sfrp2 are required for anteroposterior (AP) axis elongation and somitogenesis in the thoracic region during mouse embryogenesis. Double homozygous mutations in Sfrp1 and Sfrp2 lead to severe shortening of the thoracic region. By contrast, a homozygous mutation in one or the other exerts no effect on embryogenesis, indicating that Sfrp1 and Sfrp2 are functionally redundant. The defect of a shortened thoracic region appears to be the consequence of AP axis reduction and incomplete somite segmentation. The reduction in the AP axis is partially due to abnormalities in cell migration of pre-somitic mesoderm from the end of gastrulation. Aberrant somite segmentation is associated with altered oscillations of Notch signaling, as evidenced by abnormal Lfng and Hes7 expression during somitogenesis in the thoracic region. This study suggests that Wnt regulation by Sfrp1 and Sfrp2 is required for embryonic patterning.

CiteULike
Complore
Connotea
Del.icio.us
Digg
Reddit
Technorati
Twitter What's this?
This article has been cited by other articles:

|
 |

|
 |
 
H. Paek, G. Gutin, and J. M. Hebert
FGF signaling is strictly required to maintain early telencephalic precursor cell survival
Development,
July 15, 2009;
136(14):
2457 - 2465.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Li, S. A. Rankin, D. Sinner, A. P. Kenny, P. A. Krieg, and A. M. Zorn
Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling
Genes & Dev.,
November 1, 2008;
22(21):
3050 - 3063.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Bovolenta, P. Esteve, J. M. Ruiz, E. Cisneros, and J. Lopez-Rios
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
J. Cell Sci.,
March 15, 2008;
121(6):
737 - 746.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Li, H. Liu, L. Qin, J. Tamasi, M. Bergenstock, S. Shapses, J. H. M. Feyen, D. A. Notterman, and N. C. Partridge
Determination of Dual Effects of Parathyroid Hormone on Skeletal Gene Expression in Vivo by Microarray and Network Analysis
J. Biol. Chem.,
November 9, 2007;
282(45):
33086 - 33097.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Peng and M. Westerfield
Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists
Development,
August 15, 2006;
133(16):
3191 - 3200.
[Abstract]
[Full Text]
[PDF]
|
 |
|
© The Company of Biologists Ltd 2006