spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 15 Feb 2006
doi: 10.1242/dev.02279

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02279v1
dev.02279v2
133/6/1125    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milan, D. J.
Right arrow Articles by MacRae, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milan, D. J.
Right arrow Articles by MacRae, C. A.

Research article

(2006)Notch1b and neuregulin are required for specification of central cardiac conduction tissue


David J. Milan*, Andrea C. Giokas, Fabrizio C. Serluca, Randall T. Peterson, and Calum A. MacRae
* Author for correspondence (e-mail: dmilan{at}partners.org)

Normal heart function is critically dependent on the timing and coordination provided by a complex network of specialized cells: the cardiac conduction system. We have employed functional assays in zebrafish to explore early steps in the patterning of the conduction system that previously have been inaccessible. We demonstrate that a ring of atrioventricular conduction tissue develops at 40 hours post-fertilization in the zebrafish heart. Analysis of the mutant cloche reveals a requirement for endocardial signals in the formation of this tissue. The differentiation of these specialized cells, unlike that of adjacent endocardial cushions and valves, is not dependent on blood flow or cardiac contraction. Finally, both neuregulin and notch1b are necessary for the development of atrioventricular conduction tissue. These results are the first demonstration of the endocardial signals required for patterning central 'slow' conduction tissue, and they reveal the operation of distinct local endocardial-myocardial interactions within the developing heart tube.


This article has been cited by other articles:


Home page
 Toxicol SciHome page
V. Mehta, R. E. Peterson, and W. Heideman
2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Prevents Cardiac Valve Formation in Developing Zebrafish
Toxicol. Sci., August 1, 2008; 104(2): 303 - 311.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Honjo, J. Kniss, and J. S. Eisen
Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons
Development, August 1, 2008; 135(15): 2615 - 2625.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
N. C. Chi, R. M. Shaw, S. De Val, G. Kang, L. Y. Jan, B. L. Black, and D. Y.R. Stainier
Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
Genes & Dev., March 15, 2008; 22(6): 734 - 739.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Arnaout, T. Ferrer, J. Huisken, K. Spitzer, D. Y. R. Stainier, M. Tristani-Firouzi, and N. C. Chi
Zebrafish model for human long QT syndrome
PNAS, July 3, 2007; 104(27): 11316 - 11321.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. G. Holtzman, J. J. Schoenebeck, H.-J. Tsai, and D. Yelon
Endocardium is necessary for cardiomyocyte movement during heart tube assembly
Development, June 15, 2007; 134(12): 2379 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. D. Leslie, L. Ariza-McNaughton, A. L. Bermange, R. McAdow, S. L. Johnson, and J. Lewis
Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis
Development, March 1, 2007; 134(5): 839 - 844.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. D. Mably, L. P. Chuang, F. C. Serluca, M.-A. P. K. Mohideen, J.-N. Chen, and M. C. Fishman
santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish
Development, August 15, 2006; 133(16): 3139 - 3146.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006