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Development ePress online publication date 3 May 2006
doi: 10.1242/dev.02381

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Research article

Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium


Mahua Mukhopadhyay, Marat Gorivodsky, Svetlana Shtrom, Alexander Grinberg, Christoph Niehrs, Maria I. Morasso, and Heiner Westphal*
* Author for correspondence (e-mail: hw{at}mail.nih.gov)

The Dkk family of secreted cysteine-rich proteins regulates Wnt/{beta}-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated repression of the Wnt/{beta}-catenin pathway is essential to promote differentiation of the corneal epithelial progenitor cells into a non-keratinizing stratified epithelium. Complete transformation of the corneal epithelium into a stratified epithelium that expresses epidermal-specific differentiation markers and develops appendages such as hair follicles is achieved in the absence of the Dkk2 gene function. We show that Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium.


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