spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 21 Jun 2006
doi: 10.1242/dev.02457


This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02457v1
133/15/3005    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sakaki-Yumoto, M.
Right arrow Articles by Nishinakamura, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sakaki-Yumoto, M.
Right arrow Articles by Nishinakamura, R.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article: Development and Disease

The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development


Masayo Sakaki-Yumoto, Chiyoko Kobayashi, Akira Sato, Sayoko Fujimura, Yuko Matsumoto, Minoru Takasato, Tatsuhiko Kodama, Hiroyuki Aburatani, Makoto Asashima, Nobuaki Yoshida, and Ryuichi Nishinakamura*
* Author for correspondence (e-mail: ryuichi{at}kaiju.medic.kumamoto-u.ac.jp)

Mutations in SALL4, the human homolog of the Drosophila homeotic gene spalt (sal), cause the autosomal dominant disorder known as Okihiro syndrome. In this study, we show that a targeted null mutation in the mouse Sall4 gene leads to lethality during peri-implantation. Growth of the inner cell mass from the knockout blastocysts was reduced, and Sall4-null embryonic stem (ES) cells proliferated poorly with no aberrant differentiation. Furthermore, we demonstrated that anorectal and heart anomalies in Okihiro syndrome are caused by Sall4 haploinsufficiency and that Sall4/Sall1 heterozygotes exhibited an increased incidence of anorectal and heart anomalies, exencephaly and kidney agenesis. Sall4 and Sall1 formed heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
GENES CELLSHome page
N. Tsubooka, T. Ichisaka, K. Okita, K. Takahashi, M. Nakagawa, and S. Yamanaka
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Genes Cells, June 1, 2009; 14(6): 683 - 694.
[Abstract] [Full Text] [PDF]


Home page
Toxicol SciHome page
M. Jergil, K. Kultima, A.-L. Gustafson, L. Dencker, and M. Stigson
Valproic Acid-Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects
Toxicol. Sci., March 1, 2009; 108(1): 132 - 148.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
Y. Kawakami, Y. Uchiyama, C. Rodriguez Esteban, T. Inenaga, N. Koyano-Nakagawa, H. Kawakami, M. Marti, M. Kmita, P. Monaghan-Nichols, R. Nishinakamura, et al.
Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities
Development, February 15, 2009; 136(4): 585 - 594.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. Yang, L. Chai, T. C. Fowles, Z. Alipio, D. Xu, L. M. Fink, D. C. Ward, and Y. Ma
Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
PNAS, December 16, 2008; 105(50): 19756 - 19761.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
J. Bohm, A. Buck, W. Borozdin, A. U. Mannan, U. Matysiak-Scholze, I. Adham, W. Schulz-Schaeffer, T. Floss, W. Wurst, J. Kohlhase, et al.
Sall1, Sall2, and Sall4 Are Required for Neural Tube Closure in Mice
Am. J. Pathol., November 1, 2008; 173(5): 1455 - 1463.
[Abstract] [Full Text] [PDF]


Home page
Cereb CortexHome page
S. J. Harrison, R. Nishinakamura, and A. P. Monaghan
Sall1 Regulates Mitral Cell Development and Olfactory Nerve Extension in the Developing Olfactory Bulb
Cereb Cortex, July 1, 2008; 18(7): 1604 - 1617.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. Barembaum and M. Bronner-Fraser
Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm
Development, November 1, 2007; 134(21): 3805 - 3814.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Q. Zhou, H. Chipperfield, D. A. Melton, and W. H. Wong
A gene regulatory network in mouse embryonic stem cells
PNAS, October 16, 2007; 104(42): 16438 - 16443.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Niwa
How is pluripotency determined and maintained?
Development, February 15, 2007; 134(4): 635 - 646.
[Abstract] [Full Text] [PDF]


Home page
GENES CELLSHome page
K. Yamashita, A. Sato, M. Asashima, P.-C. Wang, and R. Nishinakamura
Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains.
Genes Cells, February 1, 2007; 12(2): 171 - 182.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Q. Wu, X. Chen, J. Zhang, Y.-H. Loh, T.-Y. Low, W. Zhang, W. Zhang, S.-K. Sze, B. Lim, and H.-H. Ng
Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells
J. Biol. Chem., August 25, 2006; 281(34): 24090 - 24094.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2006