spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 4 Oct 2006
doi: 10.1242/dev.02600

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02600v1
133/21/4151    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Armentano, M.
Right arrow Articles by Studer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Armentano, M.
Right arrow Articles by Studer, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth


Maria Armentano, Alessandro Filosa, Gennaro Andolfi, and Michèle Studer*
* Author for correspondence (e-mail: studer{at}tigem.it)

The transcription factor COUP-TFI (NR2F1), an orphan member of the nuclear receptor superfamily, is an important regulator of neurogenesis, cellular differentiation and cell migration. In the forebrain, COUP-TFI controls the connectivity between thalamus and cortex and neuronal tangential migration in the basal telencephalon. Here, we show that COUP-TFI is required for proper axonal growth and guidance of all major forebrain commissures. Fibres of the corpus callosum, the hippocampal commissure and the anterior commissure project aberrantly and fail to cross the midline in COUP-TFI null mutants. Moreover, hippocampal neurons lacking COUP-TFI have a defect in neurite outgrowth and show an abnormal axonal morphology. To search for downstream effectors, we used microarray analysis and showed that, in the absence of COUP-TFI, expression of various cytoskeleton molecules involved in neuronal morphogenesis is affected. Diminished protein levels of the microtubule-associated protein MAP1B and increased levels of the GTP-binding protein RND2 were confirmed in the developing cortex in vivo and in primary hippocampal neurons in vitro. Therefore, based on morphological studies, gene expression profiling and primary cultured neurons, the present data uncover a previously unappreciated intrinsic role for COUP-TFI in axonal growth in vivo and supply one of the premises for COUP-TFI coordination of neuronal morphogenesis in the developing forebrain.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DMMHome page
X. Miro, X. Zhou, S. Boretius, T. Michaelis, C. Kubisch, G. Alvarez-Bolado, and P. Gruss
Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube
Dis. Model. Mech., July 1, 2009; 2(7-8): 412 - 418.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Cardoso, A. Boys, E. Parrini, C. Mignon-Ravix, J. M. McMahon, S. Khantane, E. Bertini, E. Pallesi, C. Missirian, O. Zuffardi, et al.
Periventricular heterotopia, mental retardation, and epilepsy associated with 5q14.3-q15 deletion
Neurology, March 3, 2009; 72(9): 784 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
J. F. Robinson, X. Yu, S. Hong, W. C. Griffith, R. Beyer, E. Kim, and E. M. Faustman
Cadmium-Induced Differential Toxicogenomic Response in Resistant and Sensitive Mouse Strains Undergoing Neurulation
Toxicol. Sci., January 1, 2009; 107(1): 206 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. Faedo, G. S. Tomassy, Y. Ruan, H. Teichmann, S. Krauss, S. J. Pleasure, S. Y. Tsai, M.-J. Tsai, M. Studer, and J. L. R. Rubenstein
COUP-TFI Coordinates Cortical Patterning, Neurogenesis, and Laminar Fate and Modulates MAPK/ERK, AKT, and ss-Catenin Signaling
Cereb Cortex, September 1, 2008; 18(9): 2117 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Cao, G. Carlesso, A. B. Osipovich, J. Llanes, Q. Lin, K. L. Hoek, W. N. Khan, and H. E. Ruley
Subunit 1 of the Prefoldin Chaperone Complex Is Required for Lymphocyte Development and Function
J. Immunol., July 1, 2008; 181(1): 476 - 484.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006