spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 18 Oct 2006
doi: 10.1242/dev.02609

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02609v1
133/22/4495    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by de Navas, L. F.
Right arrow Articles by Sánchez-Herrero, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by de Navas, L. F.
Right arrow Articles by Sánchez-Herrero, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway


Luis F. de Navas, Daniel L. Garaulet, and Ernesto Sánchez-Herrero*
* Author for correspondence (e-mail: esherrero{at}cbm.uam.es)

The halteres and wings of Drosophila are homologous thoracic appendages, which share common positional information provided by signaling pathways. The activity in the haltere discs of the Ultrabithorax (Ubx) Hox gene establishes the differences between these structures, their different size being an obvious one. We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the size difference. Ubx downregulates dpp transcription and reduces Dpp diffusion by repressing the expression of master of thick veins and division abnormally delayed and by increasing the levels of thick veins, one of the Dpp receptors. Our results suggest that modulation in Dpp expression and spread accounts, in part, for the different size of halteres and wings.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Baena-Lopez, I. Rodriguez, and A. Baonza
The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like
PNAS, July 15, 2008; 105(28): 9645 - 9650.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. Lebreton, C. Faucher, D. L. Cribbs, and C. Benassayag
Timing of Wingless signalling distinguishes maxillary and antennal identities in Drosophila melanogaster
Development, July 1, 2008; 135(13): 2301 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
I. Gonzalez, R. Aparicio, and A. Busturia
Functional Characterization of the dRYBP Gene in Drosophila
Genetics, July 1, 2008; 179(3): 1373 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. A. Crickmore and R. S. Mann
Hox control of morphogen mobility and organ development through regulation of glypican expression
Development, January 15, 2007; 134(2): 327 - 334.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006