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Development ePress online publication date 20 Aug 2008
doi: 10.1242/dev.026443

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Research report

GATA transcription factors integrate Wnt signalling during heart development


Boni A. Afouda, Jennifer Martin, Fei Liu, Aldo Ciau-Uitz, Roger Patient, and Stefan Hoppler*
* Author for correspondence (e-mail: s.p.hoppler{at}abdn.ac.uk)

Cardiogenesis is inhibited by canonical Wnt/{beta}-catenin signalling and stimulated by non-canonical Wnt11/Jnk signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/{beta}-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides {beta}-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.




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B. A. Afouda, J. Martin, F. Liu, A. Ciau-Uitz, R. Patient, and S. Hoppler
GATA transcription factors integrate Wnt signalling during heart development
J. Cell Sci., October 1, 2008; 121(19): e1906 - e1906.
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