spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 13 Dec 2006
doi: 10.1242/dev.02728

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02728v1
134/2/367    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ninov, N.
Right arrow Articles by Martín-Blanco, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ninov, N.
Right arrow Articles by Martín-Blanco, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis


Nikolay Ninov, Dominic A. Chiarelli, and Enrique Martín-Blanco*
* Author for correspondence (e-mail: embbmc{at}cid.csic.es)

The fusion of epithelial sheets is an essential morphogenetic event. Here, we study the development of the abdomen of Drosophila as a model of bounded epithelia expansion and uncover a complex multistep process for the generation of the adult epidermis from histoblasts, founder cells that replace the larval cells during metamorphosis. We find that histoblasts experience a biphasic cell cycle and emit apical projections that direct their invasive planar intercalation in between larval cells. Coordinately, the larval cells extrude from the epithelia by apical constriction of an actomyosin ring and as a consequence die by apoptosis and are removed by circulating haemocytes. We demonstrate that the proliferation of histoblasts and the death of larval cells are triggered by two independent extrinsic Ecdysone hormonal pulses. Finally, we show that histoblast spreading and the death of larval cells depend on a mutual exchange of signals and are non-autonomous processes.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
A. Koto, E. Kuranaga, and M. Miura
Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development
J. Cell Biol., October 19, 2009; 187(2): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. Slattum, K. M. McGee, and J. Rosenblatt
P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
J. Cell Biol., September 7, 2009; 186(5): 693 - 702.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Bischoff and Z. Cseresnyes
Cell rearrangements, cell divisions and cell death in a migrating epithelial sheet in the abdomen of Drosophila
Development, July 15, 2009; 136(14): 2403 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
Y. Toyama, X. G. Peralta, A. R. Wells, D. P. Kiehart, and G. S. Edwards
Apoptotic Force and Tissue Dynamics During Drosophila Embryogenesis
Science, September 19, 2008; 321(5896): 1683 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. Ratan, D. A. Mason, B. Sinnot, D. S. Goldfarb, and R. J. Fleming
Drosophila Importin {alpha}1 Performs Paralog-Specific Functions Essential For Gametogenesis
Genetics, February 1, 2008; 178(2): 839 - 850.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006