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Development ePress online publication date 3 Jan 2007
doi: 10.1242/dev.02739

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Research article

Wnt11/{beta}-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin


Matt Kofron, Bilge Birsoy, Douglas Houston, Qinghua Tao, Christopher Wylie, and Janet Heasman*
* Author for correspondence (e-mail: heabq9{at}chmcc.org)

Current models of canonical Wnt signaling assume that a pathway is active if {beta}-catenin becomes nuclearly localized and Wnt target genes are transcribed. We show that, in Xenopus, maternal LRP6 is essential in such a pathway, playing a pivotal role in causing expression of the organizer genes siamois and Xnr3, and in establishing the dorsal axis. We provide evidence that LRP6 acts by degrading axin protein during the early cleavage stage of development. In the full-grown oocyte, before maturation, we find that axin levels are also regulated by Wnt11 and LRP6. In the oocyte, Wnt11 and/or LRP6 regulates axin to maintain {beta}-catenin at a low level, while in the embryo, asymmetrical Wnt11/LRP6 signaling stabilizes {beta}-catenin and enriches it on the dorsal side. This suggests that canonical Wnt signaling may not exist in simple off or on states, but may also include a third, steady-state, modality.


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© The Company of Biologists Ltd 2007