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Development ePress online publication date 28 Feb 2007
doi: 10.1242/dev.02828

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134/7/1431    most recent
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Research article

Shroom family proteins regulate {gamma}-tubulin distribution and microtubule architecture during epithelial cell shape change


Chanjae Lee, Heather M. Scherr, and John B. Wallingford*
* Author for correspondence (e-mail: wallingford{at}mail.utexas.edu)

Cell shape changes require the coordination of actin and microtubule cytoskeletons. The molecular mechanisms by which such coordination is achieved remain obscure, particularly in the context of epithelial cells within developing vertebrate embryos. We have identified a novel role for the actin-binding protein Shroom3 as a regulator of the microtubule cytoskeleton during epithelial morphogenesis. We show that Shroom3 is sufficient and also necessary to induce a redistribution of the microtubule regulator {gamma}-tubulin. Moreover, this change in {gamma}-tubulin distribution underlies the assembly of aligned arrays of microtubules that drive apicobasal cell elongation. Finally, experiments with the related protein, Shroom1, demonstrate that {gamma}-tubulin regulation is a conserved feature of this protein family. Together, the data demonstrate that Shroom family proteins govern epithelial cell behaviors by coordinating the assembly of both microtubule and actin cytoskeletons.




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