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Fig. 1. Frizzled receptors, their chimeras and the phenotype they control. (A) The Frizzled class proteins are serpentine receptors. Each has a large extra cellular domain (N terminus) with a cysteine-rich domain (loops), a transmembrane domain region containing the seven transmembrane helices and the associated intra- and extra-cellular loops, and an intracellular domain (C terminus) of variable length. Chimeras were constructed by splicing the Fz (red) domains to Fz2 (blue) domains. (B) The wing (i) contains two features relevant to the signaling of the two receptors. Wg signaling organizes the wing margin, most notably the large bristles on the anterior margin (ii, iv). On the blade of the wing each cell is decorated with a small hair. Collectively the small hairs point to the distal end of the wing (iii, v). (C) The shape of the ommatidia indicate the polarity in the eye (the different chiral forms are shown as red or blue). In each half of the eye all ommatidia are of the same shape and this indicates polarity running from the midline of the eye towards the dorsal and ventral extremes (arrowheads).
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