spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Summary Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brody, T.
Right arrow Articles by Odenwald, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brody, T.
Right arrow Articles by Odenwald, W. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Cellular diversity in the developing nervous system: a temporal view from Drosophila

Thomas Brody and Ward F. Odenwald*

The Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD, USA



View larger version (24K):

[in a new window]
  		Fig. 1. Sequential transitions in neuroblast gene expression generate layered sublineage expression domains. During each temporal gene expression window, asymmetric NB divisions give rise to GMCs that are marked by the continued presence of the temporal factor that is expressed in the NB during its birth. These transcription factors are also detected in nascent postmitotic neurons and glia. Cells that express Hb are positioned on the inner basal surface of the developing ganglion, and are pushed deeper into the developing neuromere upon the birth of subsequent lineages. As a consequence of these transitions in NB gene expression during lineage development, layered transcription factor expression domains are formed throughout the developing CNS. The temporal factors may act as competence factors, determining the ability of the NB to generate progeny with distinct differentiative states.

 


View larger version (5K):

[in a new window]
  		Fig. 2. Crossregulation of the temporal transcription factors. Both loss- and gain-of-function studies have demonstrated cross-regulatory interactions between the temporal transcription factors. These interactions include both activation (arrows) and repression of transcription (T-bars). As detailed in the text, these regulatory interactions can both stabilize the current state and promote the next state, thus ensuring the sequential progression of temporal states during lineage development.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



© The Company of Biologists Ltd 2002