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First published online November 3, 2003
doi: 10.1242/10.1242/dev.00902

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The control of growth

Department of Biology, Duke University, Durham, NC 27708, USA

View larger version (14K): [in a new window]   Fig. 1. Insulin signaling affects many aspects of metabolism and cell physiology, with diverse and profound consequences for health and disease.

View larger version (26K): [in a new window]   Fig. 2. A compilation of some of the principal pathways and interactions discussed at the Arolla Workshop 2003. The interactions depicted here undoubtedly do not occur simultaneously, nor are all of them present in all cell types or in all species. Many of the proteins depicted are encoded by multigene families, and different homologs may be expressed in different contexts and can have different effects. Membrane associations and cytoplasmic/nuclear localizations are not indicated. Dotted arrows indicate indirect multi-step or presumptive pathways.

View larger version (21K): [in a new window]   Fig. 3. Age-specific mortality rates of adult female Drosophila under different feeding regimes. Upper curve shows results from fully fed adults. Dietary restriction was imposed from day 1 (lower curve), day 14 (blue curve) or day 21 (red curve) onward. Within 4 days of switching to dietary restriction the mortality rate became indistinguishable from those of flies of the same age that had been maintained on dietary restriction since the beginning of adult life (see Mair et al., 2003). Curves are 3-day moving averages. Modified with permission from Mair et al. (Mair et al., 2003).