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First published online May 17, 2004
doi: 10.1242/10.1242/dev.01192

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Deconstructing the genesis of animal form

Department of Cell Biology, PO Box 3709, Duke University Medical Center, Durham, NC 27710, USA

View larger version (107K): [in a new window]   Fig. 1. Effect of the Drosophila tendrils mutation on lumen formation in the terminal branches of the tracheal system. Terminal branches are formed by long cytoplasmic projections of tracheal terminal cells that develop a single membrane bound lumen within each projection (top left panel). In tendrils mutant terminal cells (top right and bottom panels), multiple convoluted lumina are seen within individual projections. Image courtesy of Boaz Levi, Amin Ghabrial and Mark Krasnow (Stanford University School of Medicine, Stanford, CA, USA).

View larger version (36K): [in a new window]   Fig. 2. The progressive stages in the morphogenesis of hollow acini-like structures that are generated by culturing MCF-10A immortalized mammary epithelial cells in basement membrane gels (Matrigel). Confocal images show solid masses at day 5 (left), structures with centrally localized apoptotic cells at day 10 (middle) and hollow structures at day 15 (right). Apoptotic cells were identified using an antibody to caspase 3 (green); laminin 5 was detected with an antibody to the g2 laminin chain (red); and nuclei were stained with DAPI (blue). Images courtesy of Kenna R. Mills and Jay Debnath (Brugge's Laboratory, Harvard Medical School, Boston, MA, USA).

View larger version (83K): [in a new window]   Fig. 3. Loss of SLIT2 function causes the formation of supernumerary ureteric buds. Expression of a Hoxb7-GFP transgene marks nephric duct-derived epithelia in mouse embryos at 11.5 days of gestation (anterior towards the top). (Left) The normal ureteric bud has emerged from the nephric duct. (Right) Supernumerary ureteric buds have formed anterior to the normal one in a Slit2-null mutant.