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First published online October 13, 2005
doi: 10.1242/10.1242/dev.02070

Development 132, 4645-4652 (2005)
Published by The Company of Biologists 2005
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microPrimer: the biogenesis and function of microRNA

Tingting Du and Phillip D. Zamore*

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA



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  		Fig. 1. The structure of human pri-miRNAs. (A) Two examples of miRNAs with their own transcription units, such as miR-21 and the polycistronic miR-17–92-1 cluster (Cai et al., 2004Go; He et al., 2005Go). (B) miRNAs that are transcribed with other genes. miR-15a~16-1 resides in the intron of a non-coding RNA (ncRNA) (Calin et al., 2004Go) and miR-106b~93~25 lies in the intron of a protein-coding RNA (Rodriguez et al., 2004Go). miR-155 is found in the exon of a ncRNA (Eis et al., 2005Go), whereas miR-198 is in the exon of a protein-coding mRNA (Cullen, 2004Go). DLEU2, deleted in lymphocytic leukemia 2; MCM7, minichromosome maintenance deficient 7; BIC, B-cell integration cluster; FSTL1, follistatin-like 1.

 


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  		Fig. 2. The miRNA biogenesis pathway. (A) Animal and (B) plant miRNA biogenesis. Mature miRNAs are indicated in red, whereas the miRNA* strands are in blue.

 

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© The Company of Biologists Ltd 2005